heterotrimeric G-protein α-subunit Gαq regulates TCR-mediated immune responses through an Lck-dependent pathway

Here, we examined the functional involvement of heterotrimeric G-proteins in TCR-induced immune responses. TCR/CD3 crosslinking resulted in activation of both Gαq and Gαs, but not Gαi-2. Targeting of Gαs, Gαi-2 and Gαq using siRNA demonstrated a specific role of Gαq in TCR signaling. Jurkat TAg T ce...

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Veröffentlicht in:	European journal of immunology 2008-11, Vol.38 (11), p.3208-3218
Hauptverfasser:	Ngai, Jacob, Methi, Trond, Andressen, Kjetil Wessel, Levy, Finn Olav, Torgersen, Knut Martin, Vang, Torkel, Wettschureck, Nina, Taskén, Kjetil
Format:	Artikel
Sprache:	eng
Schlagworte:	Signal transduction T cells TCR Transgenic/knockout mice
Online-Zugang:	Volltext
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