The CD3 γϵ/δϵ signaling module provides normal T cell functions in the absence of the TCR ζ immunoreceptor tyrosine‐based activation motifs

T cell receptor (TCR) signal transduction is mediated by the immunoreceptor tyrosine‐based activation motifs (ITAM). The ten ITAM in the TCR complex are distributed in two distinct signaling modules termed TCR ζζ and CD3 γϵ/δϵ. To delineate the specific role of the ζ ITAM in T cell development and T...

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Veröffentlicht in:	European journal of immunology 2005-12, Vol.35 (12), p.3643-3654
Hauptverfasser:	Pitcher, Lisa A., Mathis, Meredith A., Young, Jennifer A., DeFord, Laura M., Purtic, Bozidar, Wulfing, Christoph, van Oers, Nicolai S. C.
Format:	Artikel
Sprache:	eng
Schlagworte:	Biochemistry Developmental immunology Signal transduction TCR
Online-Zugang:	Volltext
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