Increase of intracellular calcium is the essential signal for the expression of CD40 ligand

CD40 ligand (CD40L) is present on activated but not on resting T cells. In contrast to the activation markers CD25 and CD71, a strong CD40L expression could be induced by calcium ionophore alone but not by phorbol 12‐myristate 13‐acetate (PMA). Ionomycin induced a very early mRNA and protein surface...

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Veröffentlicht in:	European journal of immunology 1996-04, Vol.26 (4), p.846-850
Hauptverfasser:	Nüsslein, Hubert G., Frosch, Karl‐Heinz, Woith, Walter, Lane, Peter, Kalden, Joachim R., Manger, Bernhard
Format:	Artikel
Sprache:	eng
Schlagworte:	Antibodies, Monoclonal - immunology Antibodies, Monoclonal - pharmacology Antigens, CD - analysis Antigens, Differentiation, B-Lymphocyte - analysis Calcium - physiology Calcium influx CD28 Antigens - immunology CD3 Complex - immunology CD40 Ligand Cell Separation Cyclosporine - pharmacology Egtazic Acid - pharmacology Enzyme Activation Gene Expression Regulation - physiology Humans Intracellular Fluid Ionomycin - pharmacology Ionophores - pharmacology Lymphocyte Activation - drug effects Membrane Glycoproteins - biosynthesis Membrane Glycoproteins - genetics Mitogens - pharmacology Protein Kinase C - metabolism Receptors, Interleukin-2 - analysis Receptors, Transferrin T cell activation T-Lymphocytes - drug effects T-Lymphocytes - immunology T-Lymphocytes - metabolism Tetradecanoylphorbol Acetate - pharmacology
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