Proteasome inhibitors block VCAM‐1 and ICAM‐1 gene expression in endothelial cells without affecting nuclear translocation of nuclear factor‐ϰB

Endothelial cells play a major role in recruiting leukocytes to sites of inflammation. This is accomplished, at least in part, by up‐regulation of cell surface adhesion molecules, including VCAM‐1 and ICAM‐1, in response to cytokines. In this report, we investigated the role of the proteasome comple...

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