Mapping of the HLA locus controlling C2 structural variants and linkage disequilibrium between alleles C2 2 and Bw15

Mapping of the HLA locus controlling C2 structural variants and linkage disequilibrium between alleles C2 2 and Bw15

The newly discovered polymorphism of human C2 protein analyzed by isoelectric focusing is controlled by a locus closely linked to HLA. An informative cross‐over family (HLA: A×C) indicates that this locus maps on the C side of the region. Population and family studies have shown that the C2 2 varian...

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Veröffentlicht in:European journal of immunology 1976-12, Vol.6 (12), p.916-919
Hauptverfasser: Meo, T., Bernoc, Marietta, Bernoco, D., Ceppellini, R., Atkinson, J.
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container_end_page 919
container_issue 12
container_start_page 916
container_title European journal of immunology
container_volume 6
creator Meo, T.
Bernoc, Marietta
Bernoco, D.
Ceppellini, R.
Atkinson, J.
description The newly discovered polymorphism of human C2 protein analyzed by isoelectric focusing is controlled by a locus closely linked to HLA. An informative cross‐over family (HLA: A×C) indicates that this locus maps on the C side of the region. Population and family studies have shown that the C2 2 variant is significantly associated on the haplotype with alleles Bw15 and Cw3. The fact that the “deficient” C2 mutant is in linkage disequilibrium with other HLA antigens, suggests that C2 2 and C2 0 , here tentatively considered alleles of the same locus, are not directly related by descent.
doi_str_mv 10.1002/eji.1830061216
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title Mapping of the HLA locus controlling C2 structural variants and linkage disequilibrium between alleles C2 2 and Bw15
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