Immunological effects of IgT synthesized by thetapositive cell lines
The effects of immunologlobulin (Ig) purified by affinity chromatography from two cultured T cell lines on in vitro immune responses was studied. IgT purified from both EL‐4 and WEHI‐22 suppressed the thymus‐dependent IgM response, but had no effect on thethymus‐independent IgM response. In contrast...
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| Veröffentlicht in: | European journal of immunology 1975-06, Vol.5 (6), p.429-431 |
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| container_title | European journal of immunology |
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| creator | Feldmann, Marc Boylston, A Hogg, Nancy M. |
| description | The effects of immunologlobulin (Ig) purified by affinity chromatography from two cultured T cell lines on in vitro immune responses was studied. IgT purified from both EL‐4 and WEHI‐22 suppressed the thymus‐dependent IgM response, but had no effect on thethymus‐independent IgM response. In contrast, the IgG responses to both thymus‐dependent and independent antigens were augmented at optimal concentrations of IgT. Ig of B cell origin — serum Ig, myeloma Ig, B cell surface Ig — did not have any of these effects. Because of the similarity of the effects of IgT purified from the lymphomas with the effects of T cells and their IgT, it seems likely that the IgT obtained from EL‐4 and WEHI‐22 cell lines are analogues of normal IgT and thus should be useful in elucidating some of the chemicaland biological properties of IgT. |
| doi_str_mv | 10.1002/eji.1830050615 |
| format | Article |
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IgT purified from both EL‐4 and WEHI‐22 suppressed the thymus‐dependent IgM response, but had no effect on thethymus‐independent IgM response. In contrast, the IgG responses to both thymus‐dependent and independent antigens were augmented at optimal concentrations of IgT. Ig of B cell origin — serum Ig, myeloma Ig, B cell surface Ig — did not have any of these effects. Because of the similarity of the effects of IgT purified from the lymphomas with the effects of T cells and their IgT, it seems likely that the IgT obtained from EL‐4 and WEHI‐22 cell lines are analogues of normal IgT and thus should be useful in elucidating some of the chemicaland biological properties of IgT.</description><identifier>ISSN: 0014-2980</identifier><identifier>EISSN: 1521-4141</identifier><identifier>DOI: 10.1002/eji.1830050615</identifier><language>eng</language><publisher>Weinheim: WILEY‐VCH Verlag GmbH</publisher><ispartof>European journal of immunology, 1975-06, Vol.5 (6), p.429-431</ispartof><rights>Copyright © 1975 WILEY‐VCH Verlag GmbH & Co. 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IgT purified from both EL‐4 and WEHI‐22 suppressed the thymus‐dependent IgM response, but had no effect on thethymus‐independent IgM response. In contrast, the IgG responses to both thymus‐dependent and independent antigens were augmented at optimal concentrations of IgT. Ig of B cell origin — serum Ig, myeloma Ig, B cell surface Ig — did not have any of these effects. Because of the similarity of the effects of IgT purified from the lymphomas with the effects of T cells and their IgT, it seems likely that the IgT obtained from EL‐4 and WEHI‐22 cell lines are analogues of normal IgT and thus should be useful in elucidating some of the chemicaland biological properties of IgT.</description><issn>0014-2980</issn><issn>1521-4141</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1975</creationdate><recordtype>article</recordtype><recordid>eNqFkLtOw0AURFcIJEygpd4fsLl3H45dohDAKBJNqK31PsJGazvyGpD5eoyCBB3VTDFnikPINUKGAOzG7n2GBQeQkKM8IQlKhqlAgackAUCRsrKAc3IR4x4AylyWCbmr2vat60O_81oFap2zeoy0d7TabWmcuvHVRv9pDW0mOvdRHfroR_9uqbYh0OA7Gy_JmVMh2qufXJCX-_V29Zhunh-q1e0m1QyYTB13qAVXBTRCStS5EkuFUpeONUutpAbMuWFcaaPN3MCWWJhCurxpTA6ML0h2_NVDH-NgXX0YfKuGqUaovx3Us4P618EMlEfgwwc7_bOu10_VH_YL0t9gvA</recordid><startdate>197506</startdate><enddate>197506</enddate><creator>Feldmann, Marc</creator><creator>Boylston, A</creator><creator>Hogg, Nancy M.</creator><general>WILEY‐VCH Verlag GmbH</general><scope>AAYXX</scope><scope>CITATION</scope></search><sort><creationdate>197506</creationdate><title>Immunological effects of IgT synthesized by thetapositive cell lines</title><author>Feldmann, Marc ; Boylston, A ; Hogg, Nancy M.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c2025-f3f1c43a80b4551c6a47a15c9f2b7ca5c0163d23acdcd63d0e918d85f6bbd6023</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1975</creationdate><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Feldmann, Marc</creatorcontrib><creatorcontrib>Boylston, A</creatorcontrib><creatorcontrib>Hogg, Nancy M.</creatorcontrib><collection>CrossRef</collection><jtitle>European journal of immunology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Feldmann, Marc</au><au>Boylston, A</au><au>Hogg, Nancy M.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Immunological effects of IgT synthesized by thetapositive cell lines</atitle><jtitle>European journal of immunology</jtitle><date>1975-06</date><risdate>1975</risdate><volume>5</volume><issue>6</issue><spage>429</spage><epage>431</epage><pages>429-431</pages><issn>0014-2980</issn><eissn>1521-4141</eissn><abstract>The effects of immunologlobulin (Ig) purified by affinity chromatography from two cultured T cell lines on in vitro immune responses was studied. IgT purified from both EL‐4 and WEHI‐22 suppressed the thymus‐dependent IgM response, but had no effect on thethymus‐independent IgM response. In contrast, the IgG responses to both thymus‐dependent and independent antigens were augmented at optimal concentrations of IgT. Ig of B cell origin — serum Ig, myeloma Ig, B cell surface Ig — did not have any of these effects. Because of the similarity of the effects of IgT purified from the lymphomas with the effects of T cells and their IgT, it seems likely that the IgT obtained from EL‐4 and WEHI‐22 cell lines are analogues of normal IgT and thus should be useful in elucidating some of the chemicaland biological properties of IgT.</abstract><cop>Weinheim</cop><pub>WILEY‐VCH Verlag GmbH</pub><doi>10.1002/eji.1830050615</doi><tpages>3</tpages></addata></record> |
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| ispartof | European journal of immunology, 1975-06, Vol.5 (6), p.429-431 |
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| language | eng |
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| source | Wiley Online Library Journals Frontfile Complete |
| title | Immunological effects of IgT synthesized by thetapositive cell lines |
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