HP 663: A novel compound for the treatment of glaucoma

Various studies suggest that the 7‐dihydroxypropionyl derivative of forskolin, HP 663, effectively lowers intraocular pressure (IOP) by a novel mechanism. Biochemically, HP 663 stimulates rat striatal adenylate cyclase and displays an affinity for forskolin binding sites similar to that of forskolin...

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Veröffentlicht in:	Drug development research 1988, Vol.12 (3-4), p.197-209
Hauptverfasser:	Hartman, Harold B., Roehr, Joachim E., Kotyuk, Bernard L., Kosley Jr, Raymond W., Cherill, Robert J., Petko, Wayne W., Conway, Paul G.
Format:	Artikel
Sprache:	eng
Schlagworte:	adenylate cyclase Biological and medical sciences Eye forskolin Medical sciences ocular hypertension Pharmacology. Drug treatments
Online-Zugang:	Volltext
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