Synthesis and evaluation of conformationally restricted pyridino N-alkylated nicotine analogs as nicotinic acetylcholine receptor antagonists

Previous work has shown that quaternization of the pyridine‐N atom of S‐(–)‐nicotine (NIC) affords compounds such as N‐n‐octylnicotinium iodide (NONI) and N‐n‐decylnicotinium iodide (NDNI) that act as competitive nicotinic acetylcholine receptor (nAChR) antagonists at α3β2* and α4β2* subtypes, respe...

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Veröffentlicht in:	Drug development research 2002-03, Vol.55 (3), p.173-186
Hauptverfasser:	Xu, Rui, Dwoskin, Linda P., Grinevich, Vladimir, Sumithran, Sangeetha P., Crooks, Peter A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Biological and medical sciences brain Cholinergic system dopamine release Medical sciences Neuropharmacology Neurotransmitters. Neurotransmission. Receptors nicotine derivatives Pharmacology. Drug treatments striatum α3β2 nicotinic receptor α4β2 nicotinic receptor
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