Application of 3D Mass Spectrometry Imaging to TKIs

Mass spectrometry imaging (MSI) allows visualization of endogenous and exogenous compound in tissue sections based on its molecular mass. The 3D reconstruction by MSI provides a more informative description of the tumor drug distribution compared to the high‐performance liquid chromatography method,...

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Veröffentlicht in:	Clinical pharmacology and therapeutics 2017-11, Vol.102 (5), p.748-751
Hauptverfasser:	Morosi, Lavinia, Giordano, Silvia, Falcetta, Francesca, Frapolli, Roberta, Licandro, Simonetta A., Matteo, Cristina, Zucchetti, Massimo, Ubezio, Paolo, Erba, Eugenio, Visentin, Sonja, D'Incalci, Maurizio, Davoli, Enrico
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Gold - administration & dosage Gold - metabolism Humans Imaging, Three-Dimensional - methods Imatinib Mesylate - administration & dosage Imatinib Mesylate - metabolism Mass Spectrometry - methods Metal Nanoparticles - administration & dosage Mice Neoplasms, Mesothelial - diagnostic imaging Neoplasms, Mesothelial - drug therapy Neoplasms, Mesothelial - metabolism Pleural Neoplasms - diagnostic imaging Pleural Neoplasms - drug therapy Pleural Neoplasms - metabolism Protein Kinase Inhibitors - administration & dosage Protein Kinase Inhibitors - metabolism Tissue Distribution - drug effects Tissue Distribution - physiology Xenograft Model Antitumor Assays - methods
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