On‐pump Cardiac Surgery Enhances Platelet Renewal and Impairs Aspirin Pharmacodynamics: Effects of Improved Dosing Regimens

On‐pump cardiac surgery may trigger inflammation and accelerate platelet cyclooxygenase‐1 renewal, thereby modifying low‐dose aspirin pharmacodynamics. Thirty‐seven patients on standard aspirin 100 mg once‐daily were studied before surgery and randomized within 36 hours postsurgery to 100 mg once‐da...

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Veröffentlicht in:	Clinical pharmacology and therapeutics 2017-11, Vol.102 (5), p.849-858
Hauptverfasser:	Cavalca, V, Rocca, B, Veglia, F, Petrucci, G, Porro, B, Myasoedova, V, Cristofaro, R, Turnu, L, Bonomi, A, Songia, P, Cavallotti, L, Zanobini, M, Camera, M, Alamanni, F, Parolari, A, Patrono, C, Tremoli, E
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Aged, 80 and over Aspirin - administration & dosage Blood Platelets - drug effects Blood Platelets - metabolism Coronary Artery Bypass - adverse effects Coronary Artery Bypass - trends Coronary Artery Disease - blood Coronary Artery Disease - drug therapy Coronary Artery Disease - surgery Dose-Response Relationship, Drug Female Humans Male Middle Aged Platelet Aggregation Inhibitors - administration & dosage Treatment Outcome
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