Suboptimal Exposure to Anti‐TB Drugs in a TBM/HIV+ Population Is Not Related to Antiretroviral Therapy

A placebo‐controlled trial that compares the outcomes of immediate vs. deferred initiation of antiretroviral therapy in HIV +ve tuberculous meningitis (TBM) patients was conducted in Vietnam in 2011. Here, the pharmacokinetics of rifampicin, isoniazid, pyrazinamide, and ethambutol were investigated...

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Veröffentlicht in:	Clinical pharmacology and therapeutics 2018-03, Vol.103 (3), p.449-457
Hauptverfasser:	Török, ME, Aljayyoussi, G, Waterhouse, D, Chau, TTH, Mai, NTH, Phu, NH, Hien, TT, Hope, W, Farrar, JJ, Ward, SA
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Antiretroviral Therapy, Highly Active - adverse effects Antitubercular Agents - pharmacokinetics Antitubercular Agents - therapeutic use Coinfection Double-Blind Method Drug Interactions Female HIV Seropositivity - complications HIV Seropositivity - mortality Humans Male Middle Aged Neurotoxicity Syndromes - epidemiology Neurotoxicity Syndromes - metabolism Survival Analysis Treatment Failure Tuberculosis, Meningeal - complications Tuberculosis, Meningeal - drug therapy Tuberculosis, Meningeal - mortality
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