DNA Methylation of ADME Genes

The epigenetic regulation of expression of genes involved in the absorption, distribution, metabolism, and excretion (ADME) of drugs contributes to interindividual variability in drug response. Epigenetic mechanisms include DNA methylation, histone modifications, and miRNAs. This review systematical...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Clinical pharmacology and therapeutics 2016-05, Vol.99 (5), p.512-527
Hauptverfasser:	Fisel, P, Schaeffeler, E, Schwab, M
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals DNA Methylation - genetics Drug-Related Side Effects and Adverse Reactions - genetics Epigenesis, Genetic - genetics Gene Expression Regulation Histones - genetics Humans MicroRNAs - genetics Pharmaceutical Preparations - metabolism Pharmacokinetics Precision Medicine
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	The epigenetic regulation of expression of genes involved in the absorption, distribution, metabolism, and excretion (ADME) of drugs contributes to interindividual variability in drug response. Epigenetic mechanisms include DNA methylation, histone modifications, and miRNAs. This review systematically outlines the influence of DNA methylation on ADME gene expression and highlights the consequences for interindividual variability in drug response or drug‐induced toxicity and the implications for personalized medicine.
ISSN:	0009-9236 1532-6535
DOI:	10.1002/cpt.343