Pivotal Dose of Pembrolizumab: A Dose‐Finding Strategy for Immuno‐Oncology

Despite numerous publications emphasizing the value of dose finding, drug development in oncology is dominated by the mindset that higher dose provides higher efficacy. Examples of dose finding implemented by biopharmaceutical firms can change this mindset. The purpose of this article is to outline...

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Veröffentlicht in:	Clinical pharmacology and therapeutics 2021-07, Vol.110 (1), p.200-209
Hauptverfasser:	Li, Tommy R., Chatterjee, Manash, Lala, Mallika, Abraham, Anson K., Freshwater, Tomoko, Jain, Lokesh, Sinha, Vikram, Alwis, Dinesh P., Mayawala, Kapil
Format:	Artikel
Sprache:	eng
Schlagworte:	Antibodies, Monoclonal, Humanized - administration & dosage Antibodies, Monoclonal, Humanized - pharmacokinetics Antibodies, Monoclonal, Humanized - pharmacology Antineoplastic Agents, Immunological - administration & dosage Antineoplastic Agents, Immunological - pharmacokinetics Antineoplastic Agents, Immunological - pharmacology Computer Simulation Dose-Response Relationship, Drug Drug Development Humans Models, Biological Neoplasms - drug therapy Randomized Controlled Trials as Topic
Online-Zugang:	Volltext
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