A Multipurpose First‐in‐Human Study With the Novel CXCR7 Antagonist ACT‐1004‐1239 Using CXCL12 Plasma Concentrations as Target Engagement Biomarker

The C‐X‐C chemokine receptor 7 (CXCR7) has evolved as a promising, druggable target mainly in the immunology and oncology fields modulating plasma concentrations of its ligands CXCL11 and CXCL12 through receptor‐mediated internalization. This “scavenging” activity creates concentration gradients of...

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Veröffentlicht in:	Clinical pharmacology and therapeutics 2021-06, Vol.109 (6), p.1648-1659
Hauptverfasser:	Huynh, Christine, Henrich, Andrea, Strasser, Daniel S., Boof, Marie‐Laure, Al‐Ibrahim, Mohamed, Meyer Zu Schwabedissen, Henriette E., Dingemanse, Jasper, Ufer, Mike
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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