Risk of Opioid Overdose Associated With Concomitant Use of Opioids and Skeletal Muscle Relaxants: A Population‐Based Cohort Study

The recent opioid prescribing guideline cautions about the concomitant prescribing of opioids and skeletal muscle relaxants (SMRs) given the additive central nervous system depressant effect. However, the clinical relevance remains unclear. In this retrospective cohort study, we compared the risk of...

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Veröffentlicht in:	Clinical pharmacology and therapeutics 2020-07, Vol.108 (1), p.81-89
Hauptverfasser:	Li, Yan, Delcher, Chris, Wei, Yu‐Jung Jenny, Reisfield, Gary M., Brown, Joshua D., Tighe, Patrick, Winterstein, Almut G.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Analgesics, Opioid - administration & dosage Analgesics, Opioid - adverse effects Baclofen - administration & dosage Baclofen - adverse effects Benzodiazepines - administration & dosage Benzodiazepines - adverse effects Carisoprodol - administration & dosage Carisoprodol - adverse effects Cohort Studies Drug Interactions Female Humans Male Middle Aged Neuromuscular Agents - administration & dosage Neuromuscular Agents - adverse effects Opiate Overdose - epidemiology Practice Patterns, Physicians Retrospective Studies Time Factors
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