A Scoping Review of the Evidence Behind Cytochrome P450 2D6 Isoenzyme Inhibitor Classifications

The US Food and Drug Administration (FDA) lists 22 medications as clinical inhibitors of cytochrome P450 2D6 isoenzyme, with classifications of strong, moderate, and weak. It is accepted that strong inhibitors result in nearly null enzymatic activity, but reduction caused by moderate and weak inhibi...

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Veröffentlicht in:	Clinical pharmacology and therapeutics 2020-07, Vol.108 (1), p.116-125
Hauptverfasser:	Cicali, Emily J., Smith, D. Max, Duong, Benjamin Q., Kovar, Lukas G., Cavallari, Larisa H., Johnson, Julie A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Area Under Curve Cimetidine - classification Cimetidine - pharmacokinetics Cimetidine - pharmacology Cytochrome P-450 CYP2D6 - drug effects Cytochrome P-450 CYP2D6 - metabolism Cytochrome P-450 CYP2D6 Inhibitors - classification Cytochrome P-450 CYP2D6 Inhibitors - pharmacokinetics Desvenlafaxine Succinate - classification Desvenlafaxine Succinate - pharmacokinetics Desvenlafaxine Succinate - pharmacology Fluvoxamine - classification Fluvoxamine - pharmacokinetics Fluvoxamine - pharmacology Humans
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