Clinical Aspects of Transporter‐Mediated Drug–Drug Interactions

Drug transporters play an essential role in disposition and effects of multiple drugs. Plasma concentrations of the victim drug can be modified by drug–drug interactions occurring in enterocytes (e.g., P‐glycoprotein), hepatocytes (e.g., organic anion‐transporting polypeptide 1B1 (OATP1B1)), and/or...

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Veröffentlicht in:	Clinical pharmacology and therapeutics 2019-06, Vol.105 (6), p.1386-1394
Hauptverfasser:	Gessner, Arne, König, Jörg, Fromm, Martin F.
Format:	Artikel
Sprache:	eng
Schlagworte:	Clarithromycin - adverse effects Clarithromycin - metabolism Drug Interactions - physiology Humans Kidney - drug effects Kidney - metabolism Liver - drug effects Liver - metabolism Membrane Transport Proteins - metabolism Metformin - adverse effects Metformin - metabolism Organic Cation Transport Proteins - metabolism Tissue Distribution - drug effects Tissue Distribution - physiology
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