Phase 1 and pharmacokinetic study of everolimus in combination with cetuximab and carboplatin for recurrent/metastatic squamous cell carcinoma of the head and neck

BACKGROUND Platinum‐based therapy combined with cetuximab is standard first‐line therapy for recurrent or metastatic squamous cell carcinoma of the head and neck (RMSCCHN). Preclinical studies have suggested that mammalian target of rapamycin inhibitors may overcome resistance to epidermal growth fa...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Cancer 2014-12, Vol.120 (24), p.3940-3951
Hauptverfasser:	Saba, Nabil F., Hurwitz, Selwyn J., Magliocca, Kelly, Kim, Sungjin, Owonikoko, Taofeek K., Harvey, Donald, Ramalingam, Suresh S., Chen, Zhengjia, Rogerio, Jackie, Mendel, Jennifer, Kono, Scott A., Lewis, Colleen, Chen, Amy Y., Higgins, Kristin, El‐Deiry, Mark, Wadsworth, Trad, Beitler, Jonathan J., Shin, Dong M., Sun, Shi‐Yong, Khuri, Fadlo R.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Antibodies, Monoclonal, Humanized - administration & dosage Antibodies, Monoclonal, Humanized - adverse effects Antibodies, Monoclonal, Humanized - pharmacokinetics Antineoplastic Combined Chemotherapy Protocols - pharmacokinetics Antineoplastic Combined Chemotherapy Protocols - therapeutic use Biological and medical sciences Carboplatin - administration & dosage Carboplatin - adverse effects Carboplatin - pharmacokinetics Carcinoma, Squamous Cell - drug therapy Carcinoma, Squamous Cell - metabolism Carcinoma, Squamous Cell - pathology Cetuximab Disease-Free Survival Drug Administration Schedule Everolimus everolimus in head and neck cancer everolimus in squamous cell carcinoma everolimus, cetuximab, and carboplatin Female Head and Neck Neoplasms - drug therapy Head and Neck Neoplasms - metabolism Head and Neck Neoplasms - pathology Humans Male Maximum Tolerated Dose Medical sciences Middle Aged mTOR inhibition in head and neck cancer mTOR inhibition in squamous cell carcinoma Multiple tumors. Solid tumors. Tumors in childhood (general aspects) Neoplasm Metastasis Otorhinolaryngology (head neck, general aspects and miscellaneous) Otorhinolaryngology. Stomatology pharmacokinetics, and NONMEM Recurrence Sirolimus - administration & dosage Sirolimus - adverse effects Sirolimus - analogs & derivatives Sirolimus - pharmacokinetics Squamous Cell Carcinoma of Head and Neck Tumors
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!