Preliminary characterization of oral lesions associated with inhibitors of mammalian target of rapamycin in cancer patients

BACKGROUND: Mammalian target of rapamycin (mTOR) inhibitors may have efficacy as an intervention for advanced malignancies. Oral ulceration (OU), reported as mucositis, has been a dose‐limiting toxicity for this new class of agents. An analysis of the appearance, course, and toxicity associations of...

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Veröffentlicht in:	Cancer 2010-01, Vol.116 (1), p.210-215
Hauptverfasser:	Sonis, Stephen, Treister, Nathaniel, Chawla, Sant, Demetri, George, Haluska, Frank
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Antineoplastic Agents - adverse effects aphthous stomatitis Biological and medical sciences cancer Clinical Trials, Phase I as Topic Facial bones, jaws, teeth, parodontium: diseases, semeiology Female Humans Intracellular Signaling Peptides and Proteins - antagonists & inhibitors Male mammalian target of rapamycin inhibitor Medical sciences Middle Aged mucositis Mucositis - chemically induced Neoplasms - drug therapy Non tumoral diseases Otorhinolaryngology. Stomatology Protein-Serine-Threonine Kinases - antagonists & inhibitors Sirolimus - adverse effects Sirolimus - analogs & derivatives Stomatitis - chemically induced TOR Serine-Threonine Kinases Tumors
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