NV‐128, a novel isoflavone derivative, induces caspase‐independent cell death through the Akt/mammalian target of rapamycin pathway

BACKGROUND: Resistance to apoptosis is 1 of the key events that confer chemoresistance and is mediated by the overexpression of antiapoptotic proteins, which inhibit caspase activation. The objective of this study was to evaluate whether the activation of an alternative, caspase‐independent cell dea...

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Veröffentlicht in:	Cancer 2009-07, Vol.115 (14), p.3204-3216
Hauptverfasser:	Alvero, Ayesha B., Montagna, Michele K., Chen, Rui, Kim, Ki Hyung, Kyungjin, Kim, Visintin, Irene, Fu, Han‐Hsuan, Brown, David, Mor, Gil
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antineoplastic Agents - pharmacology Antineoplastic Agents - toxicity Autophagy Biological and medical sciences Caspases - pharmacology caspase‐independent apoptosis Cell Death - drug effects Cell Line, Tumor Cell Survival - drug effects chemoresistance Chromatin - drug effects Down-Regulation Female Female genital diseases Gynecology. Andrology. Obstetrics Humans Isoflavones - pharmacology Isoflavones - toxicity mammalian target of rapamycin Medical sciences Mice Mitochondria - drug effects Oncogene Protein v-akt - metabolism ovarian cancer Ovarian Neoplasms - metabolism Ovarian Neoplasms - pathology Phosphorylation Protein Kinases - metabolism Signal Transduction TOR Serine-Threonine Kinases Tumors Xenograft Model Antitumor Assays
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