Increased inducible nitric oxide synthase in lung carcinoma of smokers

BACKGROUND. Cigarette smoking is well known to play an important role in the development of lung cancer. Inducible nitric oxide synthase (iNOS) can either promote or inhibit cell proliferation and growth, which makes its role in the development of malignant tumors controversial. The relation between...

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Veröffentlicht in:	Cancer 2008-01, Vol.112 (2), p.372-381
Hauptverfasser:	Chen, George G., Lee, Tak Wai, Xu, Hu, Yip, Johnson H. Y., Li, Mingyue, Mok, Tony S. K., Yim, Anthony P. C.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Aged, 80 and over Biological and medical sciences Caspase 3 - analysis caspase‐3 cell death cigarette smoking Female Humans lung cancer Lung Neoplasms - complications Lung Neoplasms - enzymology Male Medical sciences Middle Aged nitric oxide Nitric Oxide - biosynthesis Nitric Oxide Synthase Type II - biosynthesis Nitrosamines - toxicity Pneumology S-Nitroso-N-Acetylpenicillamine - pharmacology Smoking - metabolism Staurosporine - analogs & derivatives Staurosporine - pharmacology Tumors Tumors of the respiratory system and mediastinum
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