In utero exposure to diethylstilbestrol (DES) does not increase genomic instability in normal or neoplastic breast epithelium

BACKGROUND. In 1992, the National Cancer Institute (NCI) established the Continuation of Follow‐Up of DES‐Exposed Cohorts to study the long‐term health effects of exposure to diethylstilbestrol (DES). Genetic effects on human breast tissue have not been examined. The authors investigated whether bre...

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Veröffentlicht in:	Cancer 2006-11, Vol.107 (9), p.2122-2126
Hauptverfasser:	Larson, Pamela S., Ungarelli, Rosemarie A., de las Morenas, Antonio, Cupples, L. Adrienne, Rowlings, Kathleen, Palmer, Julie R., Rosenberg, Carol L.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Age of Onset allele imbalance Allelic Imbalance Biological and medical sciences breast cancer Breast Neoplasms - genetics Breast Neoplasms - pathology Carcinoma - genetics Carcinoma - pathology diethylstilbestrol Diethylstilbestrol - adverse effects Estrogens, Non-Steroidal - adverse effects Female Follow-Up Studies genetic instability Gynecology. Andrology. Obstetrics Humans in utero exposure Loss of Heterozygosity Mammary gland diseases Mammary Glands, Human - pathology Maternal Exposure Medical sciences microsatellite Microsatellite Instability Middle Aged Pregnancy prenatal Prenatal Exposure Delayed Effects Reference Values Tumors
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