BRAF mutations in colorectal carcinoma suggest two entities of microsatellite‐unstable tumors

BACKGROUND Alterations of BRAF have been implicated in the carcinogenesis of colorectal tumors with microsatellite instability (MSI). These alterations were attributed to defective DNA mismatch repair, which underlies MSI. It was the objective of this study to clarify the role of BRAF in colorectal...

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Veröffentlicht in:	Cancer 2005-09, Vol.104 (5), p.952-961
Hauptverfasser:	Lubomierski, Nikolaus, Plotz, Guido, Wormek, Marc, Engels, Knut, Kriener, Susanne, Trojan, Jorg, Jungling, Bernd, Zeuzem, Stefan, Raedle, Jochen
Format:	Artikel
Sprache:	eng
Schlagworte:	Adaptor Proteins, Signal Transducing Adult Aged Aged, 80 and over Biological and medical sciences Carrier Proteins colorectal carcinomas colorectal neoplasms Colorectal Neoplasms - genetics DNA Methylation DNA Repair DNA-Binding Proteins - genetics Female Gastroenterology. Liver. Pancreas. Abdomen hereditary nonpolyposis Humans Immunohistochemistry Male Medical sciences Microsatellite Repeats Middle Aged Mutation MutL Protein Homolog 1 MutS Homolog 2 Protein Neoplasm Proteins - genetics Nuclear Proteins - genetics Phenotype Promoter Regions, Genetic Proto-Oncogene Proteins - genetics Proto-Oncogene Proteins B-raf - genetics Stomach. Duodenum. Small intestine. Colon. Rectum. Anus Tumors
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