Overexpressed in anaplastic thyroid carcinoma‐1 (OEATC‐1) as a novel gene responsible for anaplastic thyroid carcinoma
BACKGROUND Anaplastic thyroid carcinoma (ATC) is one of the most fulminant human malignancies. However, the molecular carcinogenic mechanisms of ATC are understood poorly. Recently, the authors performed a cyclic DNA (cDNA) microarray analysis with 11 anaplastic thyroid carcinoma cell lines (ACLs) a...
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| Veröffentlicht in: | Cancer 2005-05, Vol.103 (9), p.1785-1790 |
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| container_title | Cancer |
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| creator | Mizutani, Kazunori Onda, Masamitsu Asaka, Shinichi Akaishi, Junko Miyamoto, Shizuyo Yoshida, Akira Nagahama, Mitsuji Ito, Kouichi Emi, Mitsuru |
| description | BACKGROUND
Anaplastic thyroid carcinoma (ATC) is one of the most fulminant human malignancies. However, the molecular carcinogenic mechanisms of ATC are understood poorly. Recently, the authors performed a cyclic DNA (cDNA) microarray analysis with 11 anaplastic thyroid carcinoma cell lines (ACLs) and discovered several novel responsible genes for ACLs and ATC. From the extended list, they focused on hypothetical and anonymous genes and investigated a novel gene, named the overexpressed in anaplastic thyroid carcinoma‐1 (OEATC‐1) gene.
METHODS
To investigate the role of the OEATC‐1 gene in ATC carcinogenesis, first, the expression levels of OEATC‐1 in ACLs, in various types of carcinoma cell lines, and in normal human tissues were examined with reverse transcriptase‐polymerase chain reaction analysis. To explore the effect of OEATC‐1 in ATC development, a cell‐growth assay was performed with KTA2 cells under OEATC‐1 gene silencing using small‐interfering RNA (siRNA).
RESULTS
OEATC‐1 was overexpressed significantly in ACLs and in other types of carcinoma cell lines with various expression levels. Conversely, in normal human tissues, OEATC‐1 was expressed weakly in placenta, kidney, spleen, thymus, small intestine, and thyroid gland. To evaluate the effects of OEATC‐1 on tumor cell growth, gene silencing was caused by transfecting the plasmid‐generating siRNA effect to KTA2 cells. Consequently, the silencing of OEATC‐1 significantly suppressed the cell growth compared with controls.
CONCLUSIONS
The current results indicated that OEATC‐1 may have some oncogenic or cell growth‐promoting function in ACL. OEATC‐1 is considered a novel responsible gene in ATC. Cancer 2005. © 2005 American Cancer Society.
The overexpressed in anaplastic thyroid carcinoma‐1 (OEATC‐1) gene was overexpressed significantly in anaplastic thyroid carcinoma cell lines and was expressed less in normal thyroid tissues and in other normal human tissues. Gene silencing of OEATC‐1 using small‐interfering RNA caused cell growth suppression, suggesting an oncogenic function of OEATC‐1 in anaplastic thyroid carcinoma. |
| doi_str_mv | 10.1002/cncr.20988 |
| format | Article |
| fullrecord | <record><control><sourceid>wiley_cross</sourceid><recordid>TN_cdi_crossref_primary_10_1002_cncr_20988</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>CNCR20988</sourcerecordid><originalsourceid>FETCH-LOGICAL-c3278-a7dea90e27d3f9ec9d468d2e35011127f489e76a335d2bbdcf55570ae15912323</originalsourceid><addsrcrecordid>eNp9kM1Kw0AURgdRbK1ufACZpQqp85PpzCxLqD9QLEgFd2Eyc6ORNAkztVpXPoLP6JOYmoK7ru534XAWB6FTSoaUEHZlK-uHjGil9lCfEi0jQmO2j_qEEBWJmD_10FEIr-0rmeCHqEeFVJqPWB99zlbg4aPxEAI4XFTYVKYpTVgWFi9f1r4uHLbG26KqF-bn65vi89lkPE828wKbgA2u6hWU-BkqwK2mqatQZCXgvPY7ZcfoIDdlgJPtHaDH68k8uY2ms5u7ZDyNLGdSRUY6MJoAk47nGqx28Ug5BlwQSimTeaw0yJHhXDiWZc7mQghJDFChKeOMD9Bl57W-DsFDnja-WBi_TilJNwHTTcD0L2ALn3Vw85YtwP2j22ItQDvgvShhvUOVJvfJQyf9BbjOfnU</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype></control><display><type>article</type><title>Overexpressed in anaplastic thyroid carcinoma‐1 (OEATC‐1) as a novel gene responsible for anaplastic thyroid carcinoma</title><source>MEDLINE</source><source>Wiley Online Library Journals Frontfile Complete</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><source>Wiley Free Content</source><source>Alma/SFX Local Collection</source><creator>Mizutani, Kazunori ; Onda, Masamitsu ; Asaka, Shinichi ; Akaishi, Junko ; Miyamoto, Shizuyo ; Yoshida, Akira ; Nagahama, Mitsuji ; Ito, Kouichi ; Emi, Mitsuru</creator><creatorcontrib>Mizutani, Kazunori ; Onda, Masamitsu ; Asaka, Shinichi ; Akaishi, Junko ; Miyamoto, Shizuyo ; Yoshida, Akira ; Nagahama, Mitsuji ; Ito, Kouichi ; Emi, Mitsuru</creatorcontrib><description>BACKGROUND
Anaplastic thyroid carcinoma (ATC) is one of the most fulminant human malignancies. However, the molecular carcinogenic mechanisms of ATC are understood poorly. Recently, the authors performed a cyclic DNA (cDNA) microarray analysis with 11 anaplastic thyroid carcinoma cell lines (ACLs) and discovered several novel responsible genes for ACLs and ATC. From the extended list, they focused on hypothetical and anonymous genes and investigated a novel gene, named the overexpressed in anaplastic thyroid carcinoma‐1 (OEATC‐1) gene.
METHODS
To investigate the role of the OEATC‐1 gene in ATC carcinogenesis, first, the expression levels of OEATC‐1 in ACLs, in various types of carcinoma cell lines, and in normal human tissues were examined with reverse transcriptase‐polymerase chain reaction analysis. To explore the effect of OEATC‐1 in ATC development, a cell‐growth assay was performed with KTA2 cells under OEATC‐1 gene silencing using small‐interfering RNA (siRNA).
RESULTS
OEATC‐1 was overexpressed significantly in ACLs and in other types of carcinoma cell lines with various expression levels. Conversely, in normal human tissues, OEATC‐1 was expressed weakly in placenta, kidney, spleen, thymus, small intestine, and thyroid gland. To evaluate the effects of OEATC‐1 on tumor cell growth, gene silencing was caused by transfecting the plasmid‐generating siRNA effect to KTA2 cells. Consequently, the silencing of OEATC‐1 significantly suppressed the cell growth compared with controls.
CONCLUSIONS
The current results indicated that OEATC‐1 may have some oncogenic or cell growth‐promoting function in ACL. OEATC‐1 is considered a novel responsible gene in ATC. Cancer 2005. © 2005 American Cancer Society.
The overexpressed in anaplastic thyroid carcinoma‐1 (OEATC‐1) gene was overexpressed significantly in anaplastic thyroid carcinoma cell lines and was expressed less in normal thyroid tissues and in other normal human tissues. Gene silencing of OEATC‐1 using small‐interfering RNA caused cell growth suppression, suggesting an oncogenic function of OEATC‐1 in anaplastic thyroid carcinoma.</description><identifier>ISSN: 0008-543X</identifier><identifier>EISSN: 1097-0142</identifier><identifier>DOI: 10.1002/cncr.20988</identifier><identifier>PMID: 15789362</identifier><language>eng</language><publisher>Hoboken: Wiley Subscription Services, Inc., A Wiley Company</publisher><subject>anaplastic thyroid carcinoma ; Carcinoma - genetics ; Carcinoma - metabolism ; Carcinoma - pathology ; Carrier Proteins - genetics ; Carrier Proteins - metabolism ; Cell Proliferation ; gene expression ; Gene Expression Regulation, Neoplastic ; Gene Silencing ; Humans ; Microarray Analysis ; OEATC‐1 ; overexpression ; Reverse Transcriptase Polymerase Chain Reaction ; RNA, Messenger - genetics ; RNA, Messenger - metabolism ; RNA, Small Interfering ; small‐interfering RNA ; Thyroid Gland - metabolism ; Thyroid Gland - pathology ; Thyroid Neoplasms - genetics ; Thyroid Neoplasms - metabolism ; Thyroid Neoplasms - pathology ; Transfection ; Tumor Cells, Cultured</subject><ispartof>Cancer, 2005-05, Vol.103 (9), p.1785-1790</ispartof><rights>Copyright © 2005 American Cancer Society</rights><rights>(c) 2005 American Cancer Society.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3278-a7dea90e27d3f9ec9d468d2e35011127f489e76a335d2bbdcf55570ae15912323</citedby><cites>FETCH-LOGICAL-c3278-a7dea90e27d3f9ec9d468d2e35011127f489e76a335d2bbdcf55570ae15912323</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fcncr.20988$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fcncr.20988$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,1427,27903,27904,45553,45554,46387,46811</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15789362$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Mizutani, Kazunori</creatorcontrib><creatorcontrib>Onda, Masamitsu</creatorcontrib><creatorcontrib>Asaka, Shinichi</creatorcontrib><creatorcontrib>Akaishi, Junko</creatorcontrib><creatorcontrib>Miyamoto, Shizuyo</creatorcontrib><creatorcontrib>Yoshida, Akira</creatorcontrib><creatorcontrib>Nagahama, Mitsuji</creatorcontrib><creatorcontrib>Ito, Kouichi</creatorcontrib><creatorcontrib>Emi, Mitsuru</creatorcontrib><title>Overexpressed in anaplastic thyroid carcinoma‐1 (OEATC‐1) as a novel gene responsible for anaplastic thyroid carcinoma</title><title>Cancer</title><addtitle>Cancer</addtitle><description>BACKGROUND
Anaplastic thyroid carcinoma (ATC) is one of the most fulminant human malignancies. However, the molecular carcinogenic mechanisms of ATC are understood poorly. Recently, the authors performed a cyclic DNA (cDNA) microarray analysis with 11 anaplastic thyroid carcinoma cell lines (ACLs) and discovered several novel responsible genes for ACLs and ATC. From the extended list, they focused on hypothetical and anonymous genes and investigated a novel gene, named the overexpressed in anaplastic thyroid carcinoma‐1 (OEATC‐1) gene.
METHODS
To investigate the role of the OEATC‐1 gene in ATC carcinogenesis, first, the expression levels of OEATC‐1 in ACLs, in various types of carcinoma cell lines, and in normal human tissues were examined with reverse transcriptase‐polymerase chain reaction analysis. To explore the effect of OEATC‐1 in ATC development, a cell‐growth assay was performed with KTA2 cells under OEATC‐1 gene silencing using small‐interfering RNA (siRNA).
RESULTS
OEATC‐1 was overexpressed significantly in ACLs and in other types of carcinoma cell lines with various expression levels. Conversely, in normal human tissues, OEATC‐1 was expressed weakly in placenta, kidney, spleen, thymus, small intestine, and thyroid gland. To evaluate the effects of OEATC‐1 on tumor cell growth, gene silencing was caused by transfecting the plasmid‐generating siRNA effect to KTA2 cells. Consequently, the silencing of OEATC‐1 significantly suppressed the cell growth compared with controls.
CONCLUSIONS
The current results indicated that OEATC‐1 may have some oncogenic or cell growth‐promoting function in ACL. OEATC‐1 is considered a novel responsible gene in ATC. Cancer 2005. © 2005 American Cancer Society.
The overexpressed in anaplastic thyroid carcinoma‐1 (OEATC‐1) gene was overexpressed significantly in anaplastic thyroid carcinoma cell lines and was expressed less in normal thyroid tissues and in other normal human tissues. Gene silencing of OEATC‐1 using small‐interfering RNA caused cell growth suppression, suggesting an oncogenic function of OEATC‐1 in anaplastic thyroid carcinoma.</description><subject>anaplastic thyroid carcinoma</subject><subject>Carcinoma - genetics</subject><subject>Carcinoma - metabolism</subject><subject>Carcinoma - pathology</subject><subject>Carrier Proteins - genetics</subject><subject>Carrier Proteins - metabolism</subject><subject>Cell Proliferation</subject><subject>gene expression</subject><subject>Gene Expression Regulation, Neoplastic</subject><subject>Gene Silencing</subject><subject>Humans</subject><subject>Microarray Analysis</subject><subject>OEATC‐1</subject><subject>overexpression</subject><subject>Reverse Transcriptase Polymerase Chain Reaction</subject><subject>RNA, Messenger - genetics</subject><subject>RNA, Messenger - metabolism</subject><subject>RNA, Small Interfering</subject><subject>small‐interfering RNA</subject><subject>Thyroid Gland - metabolism</subject><subject>Thyroid Gland - pathology</subject><subject>Thyroid Neoplasms - genetics</subject><subject>Thyroid Neoplasms - metabolism</subject><subject>Thyroid Neoplasms - pathology</subject><subject>Transfection</subject><subject>Tumor Cells, Cultured</subject><issn>0008-543X</issn><issn>1097-0142</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2005</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kM1Kw0AURgdRbK1ufACZpQqp85PpzCxLqD9QLEgFd2Eyc6ORNAkztVpXPoLP6JOYmoK7ru534XAWB6FTSoaUEHZlK-uHjGil9lCfEi0jQmO2j_qEEBWJmD_10FEIr-0rmeCHqEeFVJqPWB99zlbg4aPxEAI4XFTYVKYpTVgWFi9f1r4uHLbG26KqF-bn65vi89lkPE828wKbgA2u6hWU-BkqwK2mqatQZCXgvPY7ZcfoIDdlgJPtHaDH68k8uY2ms5u7ZDyNLGdSRUY6MJoAk47nGqx28Ug5BlwQSimTeaw0yJHhXDiWZc7mQghJDFChKeOMD9Bl57W-DsFDnja-WBi_TilJNwHTTcD0L2ALn3Vw85YtwP2j22ItQDvgvShhvUOVJvfJQyf9BbjOfnU</recordid><startdate>20050501</startdate><enddate>20050501</enddate><creator>Mizutani, Kazunori</creator><creator>Onda, Masamitsu</creator><creator>Asaka, Shinichi</creator><creator>Akaishi, Junko</creator><creator>Miyamoto, Shizuyo</creator><creator>Yoshida, Akira</creator><creator>Nagahama, Mitsuji</creator><creator>Ito, Kouichi</creator><creator>Emi, Mitsuru</creator><general>Wiley Subscription Services, Inc., A Wiley Company</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope></search><sort><creationdate>20050501</creationdate><title>Overexpressed in anaplastic thyroid carcinoma‐1 (OEATC‐1) as a novel gene responsible for anaplastic thyroid carcinoma</title><author>Mizutani, Kazunori ; Onda, Masamitsu ; Asaka, Shinichi ; Akaishi, Junko ; Miyamoto, Shizuyo ; Yoshida, Akira ; Nagahama, Mitsuji ; Ito, Kouichi ; Emi, Mitsuru</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3278-a7dea90e27d3f9ec9d468d2e35011127f489e76a335d2bbdcf55570ae15912323</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2005</creationdate><topic>anaplastic thyroid carcinoma</topic><topic>Carcinoma - genetics</topic><topic>Carcinoma - metabolism</topic><topic>Carcinoma - pathology</topic><topic>Carrier Proteins - genetics</topic><topic>Carrier Proteins - metabolism</topic><topic>Cell Proliferation</topic><topic>gene expression</topic><topic>Gene Expression Regulation, Neoplastic</topic><topic>Gene Silencing</topic><topic>Humans</topic><topic>Microarray Analysis</topic><topic>OEATC‐1</topic><topic>overexpression</topic><topic>Reverse Transcriptase Polymerase Chain Reaction</topic><topic>RNA, Messenger - genetics</topic><topic>RNA, Messenger - metabolism</topic><topic>RNA, Small Interfering</topic><topic>small‐interfering RNA</topic><topic>Thyroid Gland - metabolism</topic><topic>Thyroid Gland - pathology</topic><topic>Thyroid Neoplasms - genetics</topic><topic>Thyroid Neoplasms - metabolism</topic><topic>Thyroid Neoplasms - pathology</topic><topic>Transfection</topic><topic>Tumor Cells, Cultured</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Mizutani, Kazunori</creatorcontrib><creatorcontrib>Onda, Masamitsu</creatorcontrib><creatorcontrib>Asaka, Shinichi</creatorcontrib><creatorcontrib>Akaishi, Junko</creatorcontrib><creatorcontrib>Miyamoto, Shizuyo</creatorcontrib><creatorcontrib>Yoshida, Akira</creatorcontrib><creatorcontrib>Nagahama, Mitsuji</creatorcontrib><creatorcontrib>Ito, Kouichi</creatorcontrib><creatorcontrib>Emi, Mitsuru</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><jtitle>Cancer</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Mizutani, Kazunori</au><au>Onda, Masamitsu</au><au>Asaka, Shinichi</au><au>Akaishi, Junko</au><au>Miyamoto, Shizuyo</au><au>Yoshida, Akira</au><au>Nagahama, Mitsuji</au><au>Ito, Kouichi</au><au>Emi, Mitsuru</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Overexpressed in anaplastic thyroid carcinoma‐1 (OEATC‐1) as a novel gene responsible for anaplastic thyroid carcinoma</atitle><jtitle>Cancer</jtitle><addtitle>Cancer</addtitle><date>2005-05-01</date><risdate>2005</risdate><volume>103</volume><issue>9</issue><spage>1785</spage><epage>1790</epage><pages>1785-1790</pages><issn>0008-543X</issn><eissn>1097-0142</eissn><abstract>BACKGROUND
Anaplastic thyroid carcinoma (ATC) is one of the most fulminant human malignancies. However, the molecular carcinogenic mechanisms of ATC are understood poorly. Recently, the authors performed a cyclic DNA (cDNA) microarray analysis with 11 anaplastic thyroid carcinoma cell lines (ACLs) and discovered several novel responsible genes for ACLs and ATC. From the extended list, they focused on hypothetical and anonymous genes and investigated a novel gene, named the overexpressed in anaplastic thyroid carcinoma‐1 (OEATC‐1) gene.
METHODS
To investigate the role of the OEATC‐1 gene in ATC carcinogenesis, first, the expression levels of OEATC‐1 in ACLs, in various types of carcinoma cell lines, and in normal human tissues were examined with reverse transcriptase‐polymerase chain reaction analysis. To explore the effect of OEATC‐1 in ATC development, a cell‐growth assay was performed with KTA2 cells under OEATC‐1 gene silencing using small‐interfering RNA (siRNA).
RESULTS
OEATC‐1 was overexpressed significantly in ACLs and in other types of carcinoma cell lines with various expression levels. Conversely, in normal human tissues, OEATC‐1 was expressed weakly in placenta, kidney, spleen, thymus, small intestine, and thyroid gland. To evaluate the effects of OEATC‐1 on tumor cell growth, gene silencing was caused by transfecting the plasmid‐generating siRNA effect to KTA2 cells. Consequently, the silencing of OEATC‐1 significantly suppressed the cell growth compared with controls.
CONCLUSIONS
The current results indicated that OEATC‐1 may have some oncogenic or cell growth‐promoting function in ACL. OEATC‐1 is considered a novel responsible gene in ATC. Cancer 2005. © 2005 American Cancer Society.
The overexpressed in anaplastic thyroid carcinoma‐1 (OEATC‐1) gene was overexpressed significantly in anaplastic thyroid carcinoma cell lines and was expressed less in normal thyroid tissues and in other normal human tissues. Gene silencing of OEATC‐1 using small‐interfering RNA caused cell growth suppression, suggesting an oncogenic function of OEATC‐1 in anaplastic thyroid carcinoma.</abstract><cop>Hoboken</cop><pub>Wiley Subscription Services, Inc., A Wiley Company</pub><pmid>15789362</pmid><doi>10.1002/cncr.20988</doi><tpages>6</tpages></addata></record> |
| fulltext | fulltext |
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| ispartof | Cancer, 2005-05, Vol.103 (9), p.1785-1790 |
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| source | MEDLINE; Wiley Online Library Journals Frontfile Complete; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Wiley Free Content; Alma/SFX Local Collection |
| subjects | anaplastic thyroid carcinoma Carcinoma - genetics Carcinoma - metabolism Carcinoma - pathology Carrier Proteins - genetics Carrier Proteins - metabolism Cell Proliferation gene expression Gene Expression Regulation, Neoplastic Gene Silencing Humans Microarray Analysis OEATC‐1 overexpression Reverse Transcriptase Polymerase Chain Reaction RNA, Messenger - genetics RNA, Messenger - metabolism RNA, Small Interfering small‐interfering RNA Thyroid Gland - metabolism Thyroid Gland - pathology Thyroid Neoplasms - genetics Thyroid Neoplasms - metabolism Thyroid Neoplasms - pathology Transfection Tumor Cells, Cultured |
| title | Overexpressed in anaplastic thyroid carcinoma‐1 (OEATC‐1) as a novel gene responsible for anaplastic thyroid carcinoma |
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