A Phase I clinical trial of ixabepilone (BMS‐247550), an epothilone B analog, administered intravenously on a daily schedule for 3 days

BACKGROUND The epothilones are a novel class of microtubule‐stabilizing agents. Ixabepilone (BMS‐247550; NSC 710428) is a semisynthetic analog of the natural product epothilone B. The authors conducted a Phase I study by administering ixabepilone to patients as a 1‐hour intravenous infusion daily fo...

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Veröffentlicht in:	Cancer 2005-05, Vol.103 (9), p.1932-1938
Hauptverfasser:	Zhuang, Sen H., Agrawal, Manish, Edgerly, Maureen, Bakke, Susan, Kotz, Herb, Thambi, Paul, Rutt, Ann, Balis, Frank M., Bates, Susan, Fojo, Tito
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Aged, 80 and over BMS‐247550 Drug Administration Schedule epothilones Epothilones - therapeutic use Female Humans Infusions, Intravenous ixabepilone Male Maximum Tolerated Dose microtubules Middle Aged Neoplasms - drug therapy taxanes
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