Microscopic analysis of chromium accumulation in the bronchi and lung of chromate workers
BACKGROUND It is known that chromium is an inhaled carcinogen and an important risk factor in the development of lung carcinoma. METHODS The authors used a microscopic X‐ray fluorescence analyzer with transmitted X‐ray mapping imaging (Horiba, Kyoto, Japan) to measure the accumulation of chromium in...
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| Veröffentlicht in: | Cancer 2003-12, Vol.98 (11), p.2420-2429 |
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| creator | Kondo, Kazuya Takahashi, Yuji Ishikawa, Sumiyo Uchihara, Hiroshi Hirose, Yukiko Yoshizawa, Kiyoshi Tsuyuguchi, Masaru Takizawa, Hiromitsu Miyoshi, Takanori Sakiyama, Shoji Monden, Yasumasa |
| description | BACKGROUND
It is known that chromium is an inhaled carcinogen and an important risk factor in the development of lung carcinoma.
METHODS
The authors used a microscopic X‐ray fluorescence analyzer with transmitted X‐ray mapping imaging (Horiba, Kyoto, Japan) to measure the accumulation of chromium in 10 resected lung tissue specimens and 90 biopsy specimens from chromate workers.
RESULTS
The maximum chromium accumulation (mean ± standard deviation) in 10 resected lung tissue specimens was 197 ± 238 counts per second (cps)/mili ampere (mA) (range, 4–649 cps/mA). Chromium accumulation was scattered in six tissue specimens and diffuse in one specimen. Chromium accumulation in the proximal bronchi was less than in the bronchioles or subpleural regions of the lung. Chromium accumulation was detectable in 63 (70%) of 90 biopsy specimens, and the mean accumulation was 6.5 ± 9.2 cps/mA (range, 0–46.5 cps/mA). Chromium detected in bronchial tissue specimens was deposited in the bronchial stroma but not in the epithelium. The maximum chromium accumulations in dysplasic (n = 3), squamous metaplastic (n = 10), and normal bronchial epithelia (n = 9) in chromate workers and in normal bronchial epithelia (n = 3) in non‐chromate workers were 20.2 ± 5.4, 18.3 ± 12.2, 13.2 ± 13.4, and 3.0 ± 1.8 cps/mA, respectively. The amount of chromium accumulation significantly increased according to the progression of malignant change of the bronchial epithelium (P = 0.003).
CONCLUSIONS
Previous studies found that lung carcinoma with chromate exposure exhibited a variety of genetic abnormalities. Considering genetic aberrations and chromium accumulation in these premalignant lesions is useful for elucidating the process of carcinogenesis in chromium‐induced lung carcinoma. Cancer 2003. © 2003 American Cancer Society.
The authors microscopically evaluated the accumulation of chromium in 10 resected lung tissue specimens and 90 biopsy specimens from chromate workers. Chromium accumulation in the proximal bronchi was less than in the bronchioles or subpleural regions of the lung. In addition, chromium accumulation increased significantly according to the progression of malignant change of the bronchial epithelium. |
| doi_str_mv | 10.1002/cncr.11818 |
| format | Article |
| fullrecord | <record><control><sourceid>wiley_cross</sourceid><recordid>TN_cdi_crossref_primary_10_1002_cncr_11818</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>CNCR11818</sourcerecordid><originalsourceid>FETCH-LOGICAL-c3918-93d98c23b4c73370cdd46b613cf6e55ea8dde9e305c404bd9dba82ed792f23ff3</originalsourceid><addsrcrecordid>eNp9kE1LxDAQhoMo7rp68QdILl6ErknTNslRil-wKoiCnko6SdxoP5Zky7L_3tYuevM0DDzvO8yD0Cklc0pIfAkN-Dmlgoo9NKVE8ojQJN5HU0KIiNKEvU3QUQif_crjlB2iCU0ylhLOp-j9wYFvA7QrB1g1qtoGF3BrMSx9W7uuxgqgq7tKrV3bYNfg9dLg0rcNLF0f0Ljqmo_fgFobvGn9l_HhGB1YVQVzspsz9Hpz_ZLfRYun2_v8ahEBk1REkmkpIGZlApwxTkDrJCszysBmJk2NElobaRhJISFJqaUulYiN5jK2MbOWzdDF2Dv8Ebyxxcq7WvltQUkx-CkGP8WPnx4-G-FVV9ZG_6E7IT1wvgNUAFVZrxpw4Y9LY5lxMRTRkdu4ymz_OVnkj_nzePwbSTt_Dg</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype></control><display><type>article</type><title>Microscopic analysis of chromium accumulation in the bronchi and lung of chromate workers</title><source>MEDLINE</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><source>Wiley Free Content</source><source>Wiley Online Library All Journals</source><source>Alma/SFX Local Collection</source><creator>Kondo, Kazuya ; Takahashi, Yuji ; Ishikawa, Sumiyo ; Uchihara, Hiroshi ; Hirose, Yukiko ; Yoshizawa, Kiyoshi ; Tsuyuguchi, Masaru ; Takizawa, Hiromitsu ; Miyoshi, Takanori ; Sakiyama, Shoji ; Monden, Yasumasa</creator><creatorcontrib>Kondo, Kazuya ; Takahashi, Yuji ; Ishikawa, Sumiyo ; Uchihara, Hiroshi ; Hirose, Yukiko ; Yoshizawa, Kiyoshi ; Tsuyuguchi, Masaru ; Takizawa, Hiromitsu ; Miyoshi, Takanori ; Sakiyama, Shoji ; Monden, Yasumasa</creatorcontrib><description>BACKGROUND
It is known that chromium is an inhaled carcinogen and an important risk factor in the development of lung carcinoma.
METHODS
The authors used a microscopic X‐ray fluorescence analyzer with transmitted X‐ray mapping imaging (Horiba, Kyoto, Japan) to measure the accumulation of chromium in 10 resected lung tissue specimens and 90 biopsy specimens from chromate workers.
RESULTS
The maximum chromium accumulation (mean ± standard deviation) in 10 resected lung tissue specimens was 197 ± 238 counts per second (cps)/mili ampere (mA) (range, 4–649 cps/mA). Chromium accumulation was scattered in six tissue specimens and diffuse in one specimen. Chromium accumulation in the proximal bronchi was less than in the bronchioles or subpleural regions of the lung. Chromium accumulation was detectable in 63 (70%) of 90 biopsy specimens, and the mean accumulation was 6.5 ± 9.2 cps/mA (range, 0–46.5 cps/mA). Chromium detected in bronchial tissue specimens was deposited in the bronchial stroma but not in the epithelium. The maximum chromium accumulations in dysplasic (n = 3), squamous metaplastic (n = 10), and normal bronchial epithelia (n = 9) in chromate workers and in normal bronchial epithelia (n = 3) in non‐chromate workers were 20.2 ± 5.4, 18.3 ± 12.2, 13.2 ± 13.4, and 3.0 ± 1.8 cps/mA, respectively. The amount of chromium accumulation significantly increased according to the progression of malignant change of the bronchial epithelium (P = 0.003).
CONCLUSIONS
Previous studies found that lung carcinoma with chromate exposure exhibited a variety of genetic abnormalities. Considering genetic aberrations and chromium accumulation in these premalignant lesions is useful for elucidating the process of carcinogenesis in chromium‐induced lung carcinoma. Cancer 2003. © 2003 American Cancer Society.
The authors microscopically evaluated the accumulation of chromium in 10 resected lung tissue specimens and 90 biopsy specimens from chromate workers. Chromium accumulation in the proximal bronchi was less than in the bronchioles or subpleural regions of the lung. In addition, chromium accumulation increased significantly according to the progression of malignant change of the bronchial epithelium.</description><identifier>ISSN: 0008-543X</identifier><identifier>EISSN: 1097-0142</identifier><identifier>DOI: 10.1002/cncr.11818</identifier><identifier>PMID: 14635077</identifier><identifier>CODEN: CANCAR</identifier><language>eng</language><publisher>Hoboken: Wiley Subscription Services, Inc., A Wiley Company</publisher><subject>accumulation ; Adult ; Aged ; Biological and medical sciences ; Bronchi - chemistry ; bronchus ; Carcinoma - etiology ; chromate worker ; Chromates - toxicity ; chromium ; Chromium - analysis ; Chromium - pharmacokinetics ; Humans ; Inhalation Exposure ; lung carcinoma ; Lung Neoplasms - etiology ; lung tissue specimens ; Male ; Medical sciences ; Middle Aged ; Occupational Exposure ; Pneumology ; Precancerous Conditions - etiology ; Precancerous Conditions - pathology ; Risk Assessment ; Spectrometry, X-Ray Emission ; Tumors of the respiratory system and mediastinum</subject><ispartof>Cancer, 2003-12, Vol.98 (11), p.2420-2429</ispartof><rights>Copyright © 2003 American Cancer Society</rights><rights>2004 INIST-CNRS</rights><rights>Copyright 2003 American Cancer Society.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3918-93d98c23b4c73370cdd46b613cf6e55ea8dde9e305c404bd9dba82ed792f23ff3</citedby><cites>FETCH-LOGICAL-c3918-93d98c23b4c73370cdd46b613cf6e55ea8dde9e305c404bd9dba82ed792f23ff3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fcncr.11818$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fcncr.11818$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1416,1432,27923,27924,45573,45574,46408,46832</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=15296788$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/14635077$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kondo, Kazuya</creatorcontrib><creatorcontrib>Takahashi, Yuji</creatorcontrib><creatorcontrib>Ishikawa, Sumiyo</creatorcontrib><creatorcontrib>Uchihara, Hiroshi</creatorcontrib><creatorcontrib>Hirose, Yukiko</creatorcontrib><creatorcontrib>Yoshizawa, Kiyoshi</creatorcontrib><creatorcontrib>Tsuyuguchi, Masaru</creatorcontrib><creatorcontrib>Takizawa, Hiromitsu</creatorcontrib><creatorcontrib>Miyoshi, Takanori</creatorcontrib><creatorcontrib>Sakiyama, Shoji</creatorcontrib><creatorcontrib>Monden, Yasumasa</creatorcontrib><title>Microscopic analysis of chromium accumulation in the bronchi and lung of chromate workers</title><title>Cancer</title><addtitle>Cancer</addtitle><description>BACKGROUND
It is known that chromium is an inhaled carcinogen and an important risk factor in the development of lung carcinoma.
METHODS
The authors used a microscopic X‐ray fluorescence analyzer with transmitted X‐ray mapping imaging (Horiba, Kyoto, Japan) to measure the accumulation of chromium in 10 resected lung tissue specimens and 90 biopsy specimens from chromate workers.
RESULTS
The maximum chromium accumulation (mean ± standard deviation) in 10 resected lung tissue specimens was 197 ± 238 counts per second (cps)/mili ampere (mA) (range, 4–649 cps/mA). Chromium accumulation was scattered in six tissue specimens and diffuse in one specimen. Chromium accumulation in the proximal bronchi was less than in the bronchioles or subpleural regions of the lung. Chromium accumulation was detectable in 63 (70%) of 90 biopsy specimens, and the mean accumulation was 6.5 ± 9.2 cps/mA (range, 0–46.5 cps/mA). Chromium detected in bronchial tissue specimens was deposited in the bronchial stroma but not in the epithelium. The maximum chromium accumulations in dysplasic (n = 3), squamous metaplastic (n = 10), and normal bronchial epithelia (n = 9) in chromate workers and in normal bronchial epithelia (n = 3) in non‐chromate workers were 20.2 ± 5.4, 18.3 ± 12.2, 13.2 ± 13.4, and 3.0 ± 1.8 cps/mA, respectively. The amount of chromium accumulation significantly increased according to the progression of malignant change of the bronchial epithelium (P = 0.003).
CONCLUSIONS
Previous studies found that lung carcinoma with chromate exposure exhibited a variety of genetic abnormalities. Considering genetic aberrations and chromium accumulation in these premalignant lesions is useful for elucidating the process of carcinogenesis in chromium‐induced lung carcinoma. Cancer 2003. © 2003 American Cancer Society.
The authors microscopically evaluated the accumulation of chromium in 10 resected lung tissue specimens and 90 biopsy specimens from chromate workers. Chromium accumulation in the proximal bronchi was less than in the bronchioles or subpleural regions of the lung. In addition, chromium accumulation increased significantly according to the progression of malignant change of the bronchial epithelium.</description><subject>accumulation</subject><subject>Adult</subject><subject>Aged</subject><subject>Biological and medical sciences</subject><subject>Bronchi - chemistry</subject><subject>bronchus</subject><subject>Carcinoma - etiology</subject><subject>chromate worker</subject><subject>Chromates - toxicity</subject><subject>chromium</subject><subject>Chromium - analysis</subject><subject>Chromium - pharmacokinetics</subject><subject>Humans</subject><subject>Inhalation Exposure</subject><subject>lung carcinoma</subject><subject>Lung Neoplasms - etiology</subject><subject>lung tissue specimens</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Occupational Exposure</subject><subject>Pneumology</subject><subject>Precancerous Conditions - etiology</subject><subject>Precancerous Conditions - pathology</subject><subject>Risk Assessment</subject><subject>Spectrometry, X-Ray Emission</subject><subject>Tumors of the respiratory system and mediastinum</subject><issn>0008-543X</issn><issn>1097-0142</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2003</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kE1LxDAQhoMo7rp68QdILl6ErknTNslRil-wKoiCnko6SdxoP5Zky7L_3tYuevM0DDzvO8yD0Cklc0pIfAkN-Dmlgoo9NKVE8ojQJN5HU0KIiNKEvU3QUQif_crjlB2iCU0ylhLOp-j9wYFvA7QrB1g1qtoGF3BrMSx9W7uuxgqgq7tKrV3bYNfg9dLg0rcNLF0f0Ljqmo_fgFobvGn9l_HhGB1YVQVzspsz9Hpz_ZLfRYun2_v8ahEBk1REkmkpIGZlApwxTkDrJCszysBmJk2NElobaRhJISFJqaUulYiN5jK2MbOWzdDF2Dv8Ebyxxcq7WvltQUkx-CkGP8WPnx4-G-FVV9ZG_6E7IT1wvgNUAFVZrxpw4Y9LY5lxMRTRkdu4ymz_OVnkj_nzePwbSTt_Dg</recordid><startdate>20031201</startdate><enddate>20031201</enddate><creator>Kondo, Kazuya</creator><creator>Takahashi, Yuji</creator><creator>Ishikawa, Sumiyo</creator><creator>Uchihara, Hiroshi</creator><creator>Hirose, Yukiko</creator><creator>Yoshizawa, Kiyoshi</creator><creator>Tsuyuguchi, Masaru</creator><creator>Takizawa, Hiromitsu</creator><creator>Miyoshi, Takanori</creator><creator>Sakiyama, Shoji</creator><creator>Monden, Yasumasa</creator><general>Wiley Subscription Services, Inc., A Wiley Company</general><general>Wiley-Liss</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope></search><sort><creationdate>20031201</creationdate><title>Microscopic analysis of chromium accumulation in the bronchi and lung of chromate workers</title><author>Kondo, Kazuya ; Takahashi, Yuji ; Ishikawa, Sumiyo ; Uchihara, Hiroshi ; Hirose, Yukiko ; Yoshizawa, Kiyoshi ; Tsuyuguchi, Masaru ; Takizawa, Hiromitsu ; Miyoshi, Takanori ; Sakiyama, Shoji ; Monden, Yasumasa</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3918-93d98c23b4c73370cdd46b613cf6e55ea8dde9e305c404bd9dba82ed792f23ff3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2003</creationdate><topic>accumulation</topic><topic>Adult</topic><topic>Aged</topic><topic>Biological and medical sciences</topic><topic>Bronchi - chemistry</topic><topic>bronchus</topic><topic>Carcinoma - etiology</topic><topic>chromate worker</topic><topic>Chromates - toxicity</topic><topic>chromium</topic><topic>Chromium - analysis</topic><topic>Chromium - pharmacokinetics</topic><topic>Humans</topic><topic>Inhalation Exposure</topic><topic>lung carcinoma</topic><topic>Lung Neoplasms - etiology</topic><topic>lung tissue specimens</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Occupational Exposure</topic><topic>Pneumology</topic><topic>Precancerous Conditions - etiology</topic><topic>Precancerous Conditions - pathology</topic><topic>Risk Assessment</topic><topic>Spectrometry, X-Ray Emission</topic><topic>Tumors of the respiratory system and mediastinum</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kondo, Kazuya</creatorcontrib><creatorcontrib>Takahashi, Yuji</creatorcontrib><creatorcontrib>Ishikawa, Sumiyo</creatorcontrib><creatorcontrib>Uchihara, Hiroshi</creatorcontrib><creatorcontrib>Hirose, Yukiko</creatorcontrib><creatorcontrib>Yoshizawa, Kiyoshi</creatorcontrib><creatorcontrib>Tsuyuguchi, Masaru</creatorcontrib><creatorcontrib>Takizawa, Hiromitsu</creatorcontrib><creatorcontrib>Miyoshi, Takanori</creatorcontrib><creatorcontrib>Sakiyama, Shoji</creatorcontrib><creatorcontrib>Monden, Yasumasa</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><jtitle>Cancer</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kondo, Kazuya</au><au>Takahashi, Yuji</au><au>Ishikawa, Sumiyo</au><au>Uchihara, Hiroshi</au><au>Hirose, Yukiko</au><au>Yoshizawa, Kiyoshi</au><au>Tsuyuguchi, Masaru</au><au>Takizawa, Hiromitsu</au><au>Miyoshi, Takanori</au><au>Sakiyama, Shoji</au><au>Monden, Yasumasa</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Microscopic analysis of chromium accumulation in the bronchi and lung of chromate workers</atitle><jtitle>Cancer</jtitle><addtitle>Cancer</addtitle><date>2003-12-01</date><risdate>2003</risdate><volume>98</volume><issue>11</issue><spage>2420</spage><epage>2429</epage><pages>2420-2429</pages><issn>0008-543X</issn><eissn>1097-0142</eissn><coden>CANCAR</coden><abstract>BACKGROUND
It is known that chromium is an inhaled carcinogen and an important risk factor in the development of lung carcinoma.
METHODS
The authors used a microscopic X‐ray fluorescence analyzer with transmitted X‐ray mapping imaging (Horiba, Kyoto, Japan) to measure the accumulation of chromium in 10 resected lung tissue specimens and 90 biopsy specimens from chromate workers.
RESULTS
The maximum chromium accumulation (mean ± standard deviation) in 10 resected lung tissue specimens was 197 ± 238 counts per second (cps)/mili ampere (mA) (range, 4–649 cps/mA). Chromium accumulation was scattered in six tissue specimens and diffuse in one specimen. Chromium accumulation in the proximal bronchi was less than in the bronchioles or subpleural regions of the lung. Chromium accumulation was detectable in 63 (70%) of 90 biopsy specimens, and the mean accumulation was 6.5 ± 9.2 cps/mA (range, 0–46.5 cps/mA). Chromium detected in bronchial tissue specimens was deposited in the bronchial stroma but not in the epithelium. The maximum chromium accumulations in dysplasic (n = 3), squamous metaplastic (n = 10), and normal bronchial epithelia (n = 9) in chromate workers and in normal bronchial epithelia (n = 3) in non‐chromate workers were 20.2 ± 5.4, 18.3 ± 12.2, 13.2 ± 13.4, and 3.0 ± 1.8 cps/mA, respectively. The amount of chromium accumulation significantly increased according to the progression of malignant change of the bronchial epithelium (P = 0.003).
CONCLUSIONS
Previous studies found that lung carcinoma with chromate exposure exhibited a variety of genetic abnormalities. Considering genetic aberrations and chromium accumulation in these premalignant lesions is useful for elucidating the process of carcinogenesis in chromium‐induced lung carcinoma. Cancer 2003. © 2003 American Cancer Society.
The authors microscopically evaluated the accumulation of chromium in 10 resected lung tissue specimens and 90 biopsy specimens from chromate workers. Chromium accumulation in the proximal bronchi was less than in the bronchioles or subpleural regions of the lung. In addition, chromium accumulation increased significantly according to the progression of malignant change of the bronchial epithelium.</abstract><cop>Hoboken</cop><pub>Wiley Subscription Services, Inc., A Wiley Company</pub><pmid>14635077</pmid><doi>10.1002/cncr.11818</doi><tpages>10</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | accumulation Adult Aged Biological and medical sciences Bronchi - chemistry bronchus Carcinoma - etiology chromate worker Chromates - toxicity chromium Chromium - analysis Chromium - pharmacokinetics Humans Inhalation Exposure lung carcinoma Lung Neoplasms - etiology lung tissue specimens Male Medical sciences Middle Aged Occupational Exposure Pneumology Precancerous Conditions - etiology Precancerous Conditions - pathology Risk Assessment Spectrometry, X-Ray Emission Tumors of the respiratory system and mediastinum |
| title | Microscopic analysis of chromium accumulation in the bronchi and lung of chromate workers |
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