A smart 19 F and 1 H MRI probe with self‐immolative linker as a versatile tool for detection of enzymes
Here we report on a dual‐modal 19 F and 1 H MRI paramagnetic probe with a self‐immolative linker, Gd–DOMF–Gal. The enzymatic conversion of this probe by β ‐galactosidase resulted in a simultaneous turning on of the fluorine signal and changed ability of the Gd 3+ complex to modulate the 1 H MR signa...
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| Veröffentlicht in: | Contrast media and molecular imaging 2012-09, Vol.7 (5), p.478-483 |
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| container_title | Contrast media and molecular imaging |
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| creator | Keliris, Aneta Mamedov, Ilgar Hagberg, Gisela E. Logothetis, Nikos K. Scheffler, Klaus Engelmann, Jörn |
| description | Here we report on a dual‐modal
19
F and
1
H MRI paramagnetic probe with a self‐immolative linker, Gd–DOMF–Gal. The enzymatic conversion of this probe by
β
‐galactosidase resulted in a simultaneous turning on of the fluorine signal and changed ability of the Gd
3+
complex to modulate the
1
H MR signal intensity of the surrounding water molecules. A versatile imaging platform for monitoring a variety of enzymes by
19
F and
1
H MRI using this molecular design is proposed. Copyright © 2012 John Wiley & Sons, Ltd. |
| doi_str_mv | 10.1002/cmmi.1470 |
| format | Article |
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19
F and
1
H MRI paramagnetic probe with a self‐immolative linker, Gd–DOMF–Gal. The enzymatic conversion of this probe by
β
‐galactosidase resulted in a simultaneous turning on of the fluorine signal and changed ability of the Gd
3+
complex to modulate the
1
H MR signal intensity of the surrounding water molecules. A versatile imaging platform for monitoring a variety of enzymes by
19
F and
1
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‐galactosidase resulted in a simultaneous turning on of the fluorine signal and changed ability of the Gd
3+
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19
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19
F and
1
H MRI paramagnetic probe with a self‐immolative linker, Gd–DOMF–Gal. The enzymatic conversion of this probe by
β
‐galactosidase resulted in a simultaneous turning on of the fluorine signal and changed ability of the Gd
3+
complex to modulate the
1
H MR signal intensity of the surrounding water molecules. A versatile imaging platform for monitoring a variety of enzymes by
19
F and
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| fulltext | fulltext |
| identifier | ISSN: 1555-4309 |
| ispartof | Contrast media and molecular imaging, 2012-09, Vol.7 (5), p.478-483 |
| issn | 1555-4309 1555-4317 |
| language | eng |
| recordid | cdi_crossref_primary_10_1002_cmmi_1470 |
| source | EZB-FREE-00999 freely available EZB journals; Alma/SFX Local Collection |
| title | A smart 19 F and 1 H MRI probe with self‐immolative linker as a versatile tool for detection of enzymes |
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