Front Cover: Druggability Assessment for Selected Serine Proteases in a Pharmaceutical Industry Setting (ChemMedChem 21/2020)

Front Cover: Druggability Assessment for Selected Serine Proteases in a Pharmaceutical Industry Setting (ChemMedChem 21/2020)

The Front Cover shows the backbone representation of a protein structural ensemble for the serine protease FXa with a reticle pointing at it. The potential of targeting a protein with a drug‐like molecule plays an important role in early drug discovery. In their study, the authors address the topic...

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Veröffentlicht in:ChemMedChem 2020-11, Vol.15 (21), p.1956-1956
Hauptverfasser: Wehrhan, Leon, Hillisch, Alexander, Mundt, Stefan, Tersteegen, Adrian, Meier, Katharina
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Sprache:eng
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druggability
HTS
molecular dynamics simulation
serine proteases
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container_end_page 1956
container_issue 21
container_start_page 1956
container_title ChemMedChem
container_volume 15
creator Wehrhan, Leon
Hillisch, Alexander
Mundt, Stefan
Tersteegen, Adrian
Meier, Katharina
description The Front Cover shows the backbone representation of a protein structural ensemble for the serine protease FXa with a reticle pointing at it. The potential of targeting a protein with a drug‐like molecule plays an important role in early drug discovery. In their study, the authors address the topic of target druggability assessment. They present key insights from high‐throughput screening (HTS) and protein structure‐based druggability assessments and illustrate that conformational variability matters. More information can be found in the Full Paper by Leon Wehrhan, Katharina Meier et al.
doi_str_mv 10.1002/cmdc.202000798
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source Wiley Online Library Journals Frontfile Complete
subjects druggability
HTS
molecular dynamics simulation
serine proteases
title Front Cover: Druggability Assessment for Selected Serine Proteases in a Pharmaceutical Industry Setting (ChemMedChem 21/2020)
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