Pyrrolo[1,2‐a]quinoxalines: Insulin Mimetics that Exhibit Potent and Selective Inhibition against Protein Tyrosine Phosphatase 1B
The Front Cover shows a C2C12 cell with the inhibitor 4‐benzylpyrrolo[1,2‐a]quinoxaline targeting the α3/α6/α7 tunnel in the Protein Tyrosine Phosphatase 1B (PTP1B) represented as a ribbon diagram. The insulin receptor (clear green) and the glucose transporter (clear yellow) shown at the cell membra...
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| Veröffentlicht in: | ChemMedChem 2020-10, Vol.15 (19), p.1765-1765 |
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| creator | García‐Marín, Javier Griera, Mercedes Sánchez‐Alonso, Patricia Di Geronimo, Bruno Mendicuti, Francisco Rodríguez‐Puyol, Manuel Alajarín, Ramón Pascual‐Teresa, Beatriz Vaquero, Juan J. Rodríguez‐Puyol, Diego |
| description | The Front Cover shows a C2C12 cell with the inhibitor 4‐benzylpyrrolo[1,2‐a]quinoxaline targeting the α3/α6/α7 tunnel in the Protein Tyrosine Phosphatase 1B (PTP1B) represented as a ribbon diagram. The insulin receptor (clear green) and the glucose transporter (clear yellow) shown at the cell membrane are involved in the glucose uptake by the cell. The inhibition of PTP1B by this molecule and their analogues produces an insulin mimetic effect. This is indicated by red arrows for the glucose molecules (in sticks) crossing the cell membrane to the cytosol. Cover design by Javier García‐Marín. More information can be found in the Full Paper by Manuel Rodríguez‐Puyol, Ramón Alajarín, Juan J. Vaquero, Diego Rodríguez‐Puyol et al. |
| doi_str_mv | 10.1002/cmdc.202000710 |
| format | Article |
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The insulin receptor (clear green) and the glucose transporter (clear yellow) shown at the cell membrane are involved in the glucose uptake by the cell. The inhibition of PTP1B by this molecule and their analogues produces an insulin mimetic effect. This is indicated by red arrows for the glucose molecules (in sticks) crossing the cell membrane to the cytosol. Cover design by Javier García‐Marín. More information can be found in the Full Paper by Manuel Rodríguez‐Puyol, Ramón Alajarín, Juan J. 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The insulin receptor (clear green) and the glucose transporter (clear yellow) shown at the cell membrane are involved in the glucose uptake by the cell. The inhibition of PTP1B by this molecule and their analogues produces an insulin mimetic effect. This is indicated by red arrows for the glucose molecules (in sticks) crossing the cell membrane to the cytosol. Cover design by Javier García‐Marín. More information can be found in the Full Paper by Manuel Rodríguez‐Puyol, Ramón Alajarín, Juan J. 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| source | Wiley Online Library Journals Frontfile Complete |
| title | Pyrrolo[1,2‐a]quinoxalines: Insulin Mimetics that Exhibit Potent and Selective Inhibition against Protein Tyrosine Phosphatase 1B |
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