Structural Consequences of the 1,2,3‐Triazole as an Amide Bioisostere in Analogues of the Cystic Fibrosis Drugs VX‐809 and VX‐770

Although the 1,2,3‐triazole is a commonly used amide bioisostere in medicinal chemistry, the structural implications of this replacement have not been fully studied. Employing X‐ray crystallography and computational studies, we report the spatial and electronic consequences of replacing an amide wit...

Ausführliche Beschreibung

Bibliographische Detailangaben

Veröffentlicht in:	ChemMedChem 2020-09, Vol.15 (18), p.1720-1730
Hauptverfasser:	Doiron, Jake E., Le, Christina A., Bacsa, John, Breton, Gary W., Martin, Kenneth L., Aller, Stephen G., Turlington, Mark
Format:	Artikel
Sprache:	eng
Schlagworte:	amide bioisosteres conformation analysis hydrogen bonding triazole
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!