Pramipexole Derivatives as Potent and Selective Dopamine D 3 Receptor Agonists with Improved Human Microsomal Stability

Herein we report the synthesis and evaluation of a series of new pramipexole derivatives as highly potent and selective agonists of the dopamine‐3 (D 3 ) receptor. A number of these new compounds bind to the D 3 receptor with sub‐nanomolar affinity and show excellent selectivity (>10 000) for the...

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Veröffentlicht in:	ChemMedChem 2014-12, Vol.9 (12), p.2653-2660
Hauptverfasser:	Chen, Jianyong, Jiang, Cheng, Levant, Beth, Li, Xiaoqin, Zhao, Ting, Wen, Bo, Luo, Ruijuan, Sun, Duxin, Wang, Shaomeng
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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