Synthesis and Pharmacological Characterization of Disila-AM80 (Disila-tamibarotene) and Disila-AM580, Silicon Analogues of the RARα-Selective Retinoid Agonists AM80 (Tamibarotene) and AM580
C/Si switch: Twofold sila‐substitution (C/Si exchange) in the RARα‐selective retinoids 1 a (AM80) and 2 a (AM580) leads to 1 b (disila‐AM80) and 2 b (disila‐AM580), respectively. The chemistry and biology of the C/Si pairs are reported.
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| Veröffentlicht in: | ChemMedChem 2009-11, Vol.4 (11), p.1797-1802 |
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| creator | Tacke, Reinhold Müller, Volker Büttner, Matthias W. Lippert, W. Peter Bertermann, Rüdiger Daiß, Jürgen O. Khanwalkar, Harshal Furst, Audrey Gaudon, Claudine Gronemeyer, Hinrich |
| description | C/Si switch: Twofold sila‐substitution (C/Si exchange) in the RARα‐selective retinoids 1 a (AM80) and 2 a (AM580) leads to 1 b (disila‐AM80) and 2 b (disila‐AM580), respectively. The chemistry and biology of the C/Si pairs are reported. |
| doi_str_mv | 10.1002/cmdc.200900257 |
| format | Article |
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| language | eng |
| recordid | cdi_crossref_primary_10_1002_cmdc_200900257 |
| source | Wiley Online Library Journals Frontfile Complete |
| subjects | bioinorganic chemistry drugs receptors retinoid agonists silicon |
| title | Synthesis and Pharmacological Characterization of Disila-AM80 (Disila-tamibarotene) and Disila-AM580, Silicon Analogues of the RARα-Selective Retinoid Agonists AM80 (Tamibarotene) and AM580 |
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