Molecular Modeling of Interactions of the Benzolactam-V8 Modulators with the Cys2 Domain of Protein Kinase Cδ

Molecular modeling of interactions of four 7‐ or 8‐substituted benzolactam‐V8 (BLV) molecules with the cys2 activator‐binding domain of protein kinase C (PKCδ) was carried out using molecular docking program Autodock. The docked models reveal that the hydroxymethyl group at the C(5) atom of the eigh...

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Veröffentlicht in:	Chinese journal of chemistry 2007-10, Vol.25 (10), p.1434-1438
Hauptverfasser:	HUANG, Li-Li, MA, Da-Wei, XIA, Zong-Xiang
Format:	Artikel
Sprache:	eng
Schlagworte:	benzolactam hydrogen bond hydrophobic interaction modulator molecular docking PKCδ-binding affinity protein kinase protein-ligand interaction regulatory domain
Online-Zugang:	Volltext
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