Investigations on Mechanical Stress Caused to CHO Suspension Cells by Standard and Single-Use Pumps

Mechanical stress caused to transfected Chinese hamster ovary (CHO) suspension cells by reusable and single‐use magnetically levitated, bearingless centrifugal pumps was investigated. Cell death rates were determined for different pump speeds and compared with data from a peristaltic and a 4‐piston...

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Veröffentlicht in:	Chemie ingenieur technik 2013-02, Vol.85 (1-2), p.144-152
Hauptverfasser:	Blaschczok, Katharina, Kaiser, Stephan C., Löffelholz, Christian, Imseng, Nicole, Burkart, Jürg, Bösch, Pascal, Dornfeld, Wolfgang, Eibl, Regine, Eibl, Dieter
Format:	Artikel
Sprache:	eng
Schlagworte:	Cell death CHO cells Computational fluid dynamics modeling Mechanical stress Shear rate Single-use pump
Online-Zugang:	Volltext
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