Rac-Flurbiprofen is more ulcerogenic than its (S)-enantiomer

The most common, and sometimes life‐threatening, side‐effects associated with the human use of the analgesic, nonsteroidal antiinflammatory drugs (NSAIDs) are gastrointestinal. These include gastritis, ulceration, and severe bleeding. The aryl propionic acid class of NSAIDs are among the most widely...

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Veröffentlicht in:	Chirality (New York, N.Y.) N.Y.), 1993, Vol.5 (7), p.492-494
Hauptverfasser:	Wechter, William J., Bigornia, Annette E., Murray Jr, E. David, Levine, Barry H., Young, James W.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Digestive System - drug effects Digestive System - pathology Drug toxicity and drugs side effects treatment Female Flurbiprofen - chemistry Flurbiprofen - toxicity Gastrointestinal Diseases - chemically induced Gastrointestinal Diseases - pathology GI-side effects Jejunum - drug effects Jejunum - pathology Medical sciences Necrosis NSAID Pharmacology. Drug treatments rac-flurbiprofen enantiomers Rats Rats, Sprague-Dawley Stereoisomerism Toxicity: digestive system Ulcer - chemically induced Ulcer - pathology ulcerogenicity Weight Gain - drug effects
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