ChemInform Abstract: Asymmetric Synthesis of (S,S,S)-2-Aza-bicyclo[3.3.0]-octane-3-carboxylic Acid Benzyl Ester: Formal Synthesis of Ramipril

Using (S)‐1‐amino‐2‐(methoxymethyl)pyrrolidine (SAMP) (II) as chiral auxiliary, a new and innovative route to title compound (VIII), a key intermediate in the synthesis of the ACE inhibitor ramipril, is described.

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Veröffentlicht in:	ChemInform 2011-10, Vol.42 (41), p.no-no
Hauptverfasser:	Kondaiah, G. C. M., Vivekanandareddy, M., Reddy, L. Amarnath, Anurkar, Smita V., Gurav, V. M., Ravikumar, M., Bhattacharya, Apurba, Bandichhor, Rakeshwar
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Sprache:	eng
Schlagworte:	diastereoselective syntheses diastereoselective syntheses, enantioselective syntheses (incl. cis/trans‐isomerism) enantioselective syntheses (incl. cis/trans-isomerism) fused pyrrole derivatives medicinal chemistry pharmacology pharmacology, medicinal chemistry, vaccines, serums ring closure reactions serums vaccines
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creator	Kondaiah, G. C. M. Vivekanandareddy, M. Reddy, L. Amarnath Anurkar, Smita V. Gurav, V. M. Ravikumar, M. Bhattacharya, Apurba Bandichhor, Rakeshwar
description	Using (S)‐1‐amino‐2‐(methoxymethyl)pyrrolidine (SAMP) (II) as chiral auxiliary, a new and innovative route to title compound (VIII), a key intermediate in the synthesis of the ACE inhibitor ramipril, is described.
doi_str_mv	10.1002/chin.201141105
format	Article
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subjects	diastereoselective syntheses diastereoselective syntheses, enantioselective syntheses (incl. cis/trans‐isomerism) enantioselective syntheses (incl. cis/trans-isomerism) fused pyrrole derivatives medicinal chemistry pharmacology pharmacology, medicinal chemistry, vaccines, serums ring closure reactions serums vaccines
title	ChemInform Abstract: Asymmetric Synthesis of (S,S,S)-2-Aza-bicyclo[3.3.0]-octane-3-carboxylic Acid Benzyl Ester: Formal Synthesis of Ramipril
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