Front Cover: Multifunctional Glycoconjugates for Recruiting Natural Antibodies against Cancer Cells (Chem. Eur. J. 68/2019)
The utility of synthetic chemistry in cancer immunotherapy has been demonstrated over the past decades with antitumoral vaccines and antibody recruiting molecules (ARM). By using click chemistry, polyfunctional ARMs composed of multivalent antibody and tumoral binding modules to guide natural antibo...
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| Veröffentlicht in: | Chemistry : a European journal 2019-12, Vol.25 (68), p.15425-15425 |
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| container_end_page | 15425 |
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| container_issue | 68 |
| container_start_page | 15425 |
| container_title | Chemistry : a European journal |
| container_volume | 25 |
| creator | Liet, Benjamin Laigre, Eugénie Goyard, David Todaro, Biagio Tiertant, Claire Boturyn, Didier Berthet, Nathalie Renaudet, Olivier |
| description | The utility of synthetic chemistry in cancer immunotherapy has been demonstrated over the past decades with antitumoral vaccines and antibody recruiting molecules (ARM). By using click chemistry, polyfunctional ARMs composed of multivalent antibody and tumoral binding modules to guide natural antibodies to cancer cells without pre‐immunization step have been developed. The resulting ARM was found to promote the formation of a ternary complex that is required for the stimulation of cytotoxic immune response in vivo. More information can be found in the Full Paper by N. Berthet, O. Renaudet, et al. on page 15508. |
| doi_str_mv | 10.1002/chem.201904615 |
| format | Article |
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| ispartof | Chemistry : a European journal, 2019-12, Vol.25 (68), p.15425-15425 |
| issn | 0947-6539 1521-3765 |
| language | eng |
| recordid | cdi_crossref_primary_10_1002_chem_201904615 |
| source | Wiley-Blackwell Journals |
| subjects | antibodies cancer click chemistry glycoconjugates multivalency |
| title | Front Cover: Multifunctional Glycoconjugates for Recruiting Natural Antibodies against Cancer Cells (Chem. Eur. J. 68/2019) |
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