Multivalency Increases the Binding Strength of RGD Peptidomimetic-Paclitaxel Conjugates to Integrin α V β 3

This work reports the synthesis of three multimeric RGD peptidomimetic-paclitaxel conjugates featuring a number of α β integrin ligands ranging from 2 to 4. These constructs were assembled by conjugation of the integrin α β ligand cyclo[DKP-RGD]-CH NH with paclitaxel via a 2'-carbamate with a s...

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Veröffentlicht in:	Chemistry : a European journal 2017-10, Vol.23 (58), p.14410-14415
Hauptverfasser:	Raposo Moreira Dias, André, Pina, Arianna, Dal Corso, Alberto, Arosio, Daniela, Belvisi, Laura, Pignataro, Luca, Caruso, Michele, Gennari, Cesare
Format:	Artikel
Sprache:	eng
Schlagworte:	Biotinylation Inhibitory Concentration 50 Integrin alphaVbeta3 - chemistry Integrin alphaVbeta3 - metabolism Oligopeptides - chemistry Paclitaxel - chemistry Peptidomimetics - chemistry Peptidomimetics - metabolism Protein Binding Vitronectin - chemistry Vitronectin - metabolism
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