Facilitation of Ca 2+ -induced opening of the mitochondrial permeability transition pore either by nicotinamide nucleotide transhydrogenase deficiency or statins treatment
Mitochondrial redox imbalance and high Ca uptake induce the opening of the permeability transition pore (PTP) that leads to disruption of energy-linked mitochondrial functions and triggers cell death in many disease states. In this review, we discuss the major results from our studies investigating...
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| Veröffentlicht in: | Cell biology international 2018-06, Vol.42 (6), p.742-746 |
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| container_title | Cell biology international |
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| creator | Busanello, Estela N B Figueira, Tiago R Marques, Ana C Navarro, Claudia D C Oliveira, Helena C F Vercesi, Anibal E |
| description | Mitochondrial redox imbalance and high Ca
uptake induce the opening of the permeability transition pore (PTP) that leads to disruption of energy-linked mitochondrial functions and triggers cell death in many disease states. In this review, we discuss the major results from our studies investigating the consequences of NAD(P)-transhydrogenase (NNT) deficiency, and of statins treatment for mitochondrial functions and susceptibility to Ca
-induced PTP. We highlight the aggravation of high fat diet-induced fatty liver disease in the context of NNT deficiency and the role of antioxidants in the prevention of statins toxicity to mitochondria. |
| doi_str_mv | 10.1002/cbin.10949 |
| format | Article |
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| source | MEDLINE; Access via Wiley Online Library |
| subjects | Animals Calcium - metabolism Diet, High-Fat Fatty Liver - drug therapy Fatty Liver - etiology Fatty Liver - veterinary Hydroxymethylglutaryl-CoA Reductase Inhibitors - pharmacology Hydroxymethylglutaryl-CoA Reductase Inhibitors - therapeutic use Mitochondria - drug effects Mitochondria - metabolism Mitochondrial Membrane Transport Proteins - metabolism NADP Transhydrogenases - genetics NADP Transhydrogenases - metabolism Permeability - drug effects Ubiquinone - analogs & derivatives Ubiquinone - chemistry Ubiquinone - metabolism |
| title | Facilitation of Ca 2+ -induced opening of the mitochondrial permeability transition pore either by nicotinamide nucleotide transhydrogenase deficiency or statins treatment |
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