Front Cover: Human Cellular Retinol Binding Protein II Forms a Domain‐Swapped Trimer Representing a Novel Fold and a New Template for Protein Engineering (ChemBioChem 22/2020)

The folding pathway of human cellular retinol binding protein II was manipulated to favor formation of the shown domain‐swapped trimer, by rational protein engineering of a cross‐subunit disulfide bond. The inset shows the zinc binding site, engineered into the trimer with a single mutation, by expl...

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Veröffentlicht in:	Chembiochem : a European journal of chemical biology 2020-11, Vol.21 (22), p.3158-3158
Hauptverfasser:	Ghanbarpour, Alireza, Santos, Elizabeth M., Pinger, Cody, Assar, Zahra, Hossaini Nasr, Seyedmehdi, Vasileiou, Chrysoula, Spence, Dana, Borhan, Babak, Geiger, James H.
Format:	Artikel
Sprache:	eng
Schlagworte:	domain-swapped trimers human cellular retinol binding protein II metalloproteins protein engineering
Online-Zugang:	Volltext
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