Artificial Zinc(II) Complexes Regulate Cell Cycle and Apoptosis-Related Genes in Tumor Cell Lines

Various proteins involved in transcriptional regulation possess highly selective DNA-binding domains, known as zinc fingers. However, little is known about small-molecule zinc(II) complexes in the regulation of gene expression and programmed cell death. A new family of zinc(II) complexes is reported...

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Veröffentlicht in:	Chembiochem : a European journal of chemical biology 2007-02, Vol.8 (3), p.332-340
Hauptverfasser:	Gao, Jian, Liu, Ya-Guang, Zhou, Yaqing, Boxer, Linda M, Woolley, F. Ross, Zingaro, Ralph A
Format:	Artikel
Sprache:	eng
Schlagworte:	Antineoplastic Agents - pharmacology antitumor agents Apoptosis Apoptosis Regulatory Proteins - genetics breast cancer Breast Neoplasms - drug therapy Cell Cycle Cell Line, Tumor Down-Regulation - drug effects Female gene expression Genes, cdc - drug effects Humans Inhibitory Concentration 50 Molecular Structure Organometallic Compounds - pharmacology Proto-Oncogene Proteins c-bcl-2 - drug effects Proto-Oncogene Proteins c-bcl-2 - metabolism transcription factors zinc Zinc - chemistry
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