Synthesis and Biological Activity of a Platinum(II) 6-Phenyl-2,2′-bipyridine Complex and Its Dimeric Analogue

We have synthesized (pyridyl)-(6-phenyl-2,2′-bipyridine)platinum(II) hexafluorophosphate (1) and its corresponding dimer, μ-N,N′-bis(isonicotinyl)-1,6-hexanediamino bis-[6-phenyl-2,2′-bipyridine-platinum(II)] dichloride (2). The DNA binding constants of 1 and 2 at 20 °C were determined by absorption...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Chembiochem : a European journal of chemical biology 2003-01, Vol.4 (1), p.62-68
Hauptverfasser:	Chan, Hing-Leung, Ma, Dik-Lung, Yang, Mengsu, Che, Chi-Ming
Format:	Artikel
Sprache:	eng
Schlagworte:	Algorithms Antineoplastic Agents - chemical synthesis Antineoplastic Agents - pharmacology antitumor agents bioinorganic chemistry DNA DNA - drug effects DNA - metabolism DNA Fragmentation - drug effects Drug Screening Assays, Antitumor Electrophoretic Mobility Shift Assay Humans Indicators and Reagents intercalation Nucleic Acid Conformation Organoplatinum Compounds - chemical synthesis Organoplatinum Compounds - pharmacology platinum Pyridines - chemical synthesis Pyridines - pharmacology Reverse Transcriptase Polymerase Chain Reaction Spectrometry, Fluorescence Spectrophotometry, Ultraviolet Tetrazolium Salts Thermodynamics Thiazoles Tumor Cells, Cultured Viscosity
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!