Elucidation of the Interactions of an Anticancer Ruthenium Complex in Clinical Trials with Biomolecules Utilizing Capillary Electrophoresis Hyphenated to Inductively Coupled Plasma-Mass Spectrometry. Short Communication

The application of capillary electrophoresis (CE) combined with highly sensitive inductively‐coupled‐plasma mass spectrometric (ICP‐MS) detection allows the interactions of metal complexes with biomolecules to be characterized. This technique has been used to provide new insights into the mode of ac...

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Veröffentlicht in:	Chemistry & biodiversity 2008-08, Vol.5 (8), p.1609-1614
Hauptverfasser:	Groessl, Michael, Hartinger, Christian G., Połeć-Pawlak, Kasia, Jarosz, Maciej, Dyson, Paul J., Keppler, Bernhard K.
Format:	Artikel
Sprache:	eng
Schlagworte:	Anticancer research Antineoplastic Agents - blood Antineoplastic Agents - chemistry Antineoplastic Agents - pharmacology Binding Sites Capillary electrophoresis (CE) Clinical Trials as Topic Deoxyguanine Nucleotides - chemistry DNA DNA - chemistry Electrophoresis, Capillary - methods Humans Indazoles - blood Indazoles - chemistry Indazoles - pharmacology KP1019 Mass spectrometry Mass Spectrometry - methods Molecular Conformation Organometallic Compounds Ruthenium complexes Ruthenium Compounds - blood Ruthenium Compounds - chemistry Ruthenium Compounds - pharmacology Serum Albumin - chemistry Spectrophotometry, Ultraviolet Structure-Activity Relationship
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