Elucidation of the Interactions of an Anticancer Ruthenium Complex in Clinical Trials with Biomolecules Utilizing Capillary Electrophoresis Hyphenated to Inductively Coupled Plasma-Mass Spectrometry. Short Communication
The application of capillary electrophoresis (CE) combined with highly sensitive inductively‐coupled‐plasma mass spectrometric (ICP‐MS) detection allows the interactions of metal complexes with biomolecules to be characterized. This technique has been used to provide new insights into the mode of ac...
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| Veröffentlicht in: | Chemistry & biodiversity 2008-08, Vol.5 (8), p.1609-1614 |
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| container_title | Chemistry & biodiversity |
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| creator | Groessl, Michael Hartinger, Christian G. Połeć-Pawlak, Kasia Jarosz, Maciej Dyson, Paul J. Keppler, Bernhard K. |
| description | The application of capillary electrophoresis (CE) combined with highly sensitive inductively‐coupled‐plasma mass spectrometric (ICP‐MS) detection allows the interactions of metal complexes with biomolecules to be characterized. This technique has been used to provide new insights into the mode of action of the ruthenium‐based anticancer drug candidate indazolium [trans‐tetrachlorobis(1H‐indazole)ruthenate(III)] (KP1019). While the compound binds rapidly and efficiently to serum proteins, especially albumin, its reactivity towards the model DNA compound 2′‐deoxyguanosine 5′‐monophosphate (5′‐dGMP) is moderate. |
| doi_str_mv | 10.1002/cbdv.200890148 |
| format | Article |
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Short Communication</title><title>Chemistry & biodiversity</title><addtitle>Chemistry & Biodiversity</addtitle><description>The application of capillary electrophoresis (CE) combined with highly sensitive inductively‐coupled‐plasma mass spectrometric (ICP‐MS) detection allows the interactions of metal complexes with biomolecules to be characterized. This technique has been used to provide new insights into the mode of action of the ruthenium‐based anticancer drug candidate indazolium [trans‐tetrachlorobis(1H‐indazole)ruthenate(III)] (KP1019). While the compound binds rapidly and efficiently to serum proteins, especially albumin, its reactivity towards the model DNA compound 2′‐deoxyguanosine 5′‐monophosphate (5′‐dGMP) is moderate.</description><subject>Anticancer research</subject><subject>Antineoplastic Agents - blood</subject><subject>Antineoplastic Agents - chemistry</subject><subject>Antineoplastic Agents - pharmacology</subject><subject>Binding Sites</subject><subject>Capillary electrophoresis (CE)</subject><subject>Clinical Trials as Topic</subject><subject>Deoxyguanine Nucleotides - chemistry</subject><subject>DNA</subject><subject>DNA - chemistry</subject><subject>Electrophoresis, Capillary - methods</subject><subject>Humans</subject><subject>Indazoles - blood</subject><subject>Indazoles - chemistry</subject><subject>Indazoles - pharmacology</subject><subject>KP1019</subject><subject>Mass spectrometry</subject><subject>Mass Spectrometry - methods</subject><subject>Molecular Conformation</subject><subject>Organometallic Compounds</subject><subject>Ruthenium complexes</subject><subject>Ruthenium Compounds - blood</subject><subject>Ruthenium Compounds - chemistry</subject><subject>Ruthenium Compounds - pharmacology</subject><subject>Serum Albumin - chemistry</subject><subject>Spectrophotometry, Ultraviolet</subject><subject>Structure-Activity Relationship</subject><issn>1612-1872</issn><issn>1612-1880</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFUU1z0zAU9DAwbSm9cmTeH3CQ5cS2jq2TpmUCdJoWjhpZeiYC-WMkua35q_wZZNIJ3DhJs9rdt3obRW8TMksIoe9lpR5mlJCCkWRevIhOkiyhcVIU5OXhntPj6LVz3wM_4MVRdDxhjLDFSfRrZQaplfC6a6Grwe8QrluPVsgJchMmWjhvvZailWjhdgicVg8NlF3TG3wC3UJpdBsIBu6sFsbBo_Y7uNBd0xmUg0EH914b_VO336AUvTZG2BFW4dHbrt91Fp12cDX2wVp4VOC7EEMNIcQDmjGMGsIoBTdGuEbEH4VzsO3_qBv0dpzBNpj4KVIzTEmm8G-iV3UIg2fP52l0f7m6K6_izef1dXm-iSWlWREX83nNsixHIhOBFaGEVkxVNZlLpmRVI9Kchb3VMiwtlVJleU6FSOlCMJnUKj2NZntfaTvnLNa8t7oJH-QJ4VNLfGqJH1oKgnd7QT9UDaq_9OdaAoHtCY_a4PgfO15eLL_8ax7vtdp5fDpohf3BszzNF_zrpzVfbpflh3W24ST9DT0xtYw</recordid><startdate>200808</startdate><enddate>200808</enddate><creator>Groessl, Michael</creator><creator>Hartinger, Christian G.</creator><creator>Połeć-Pawlak, Kasia</creator><creator>Jarosz, Maciej</creator><creator>Dyson, Paul J.</creator><creator>Keppler, Bernhard K.</creator><general>WILEY-VCH Verlag</general><general>WILEY‐VCH Verlag</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope></search><sort><creationdate>200808</creationdate><title>Elucidation of the Interactions of an Anticancer Ruthenium Complex in Clinical Trials with Biomolecules Utilizing Capillary Electrophoresis Hyphenated to Inductively Coupled Plasma-Mass Spectrometry. 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Short Communication</atitle><jtitle>Chemistry & biodiversity</jtitle><addtitle>Chemistry & Biodiversity</addtitle><date>2008-08</date><risdate>2008</risdate><volume>5</volume><issue>8</issue><spage>1609</spage><epage>1614</epage><pages>1609-1614</pages><issn>1612-1872</issn><eissn>1612-1880</eissn><abstract>The application of capillary electrophoresis (CE) combined with highly sensitive inductively‐coupled‐plasma mass spectrometric (ICP‐MS) detection allows the interactions of metal complexes with biomolecules to be characterized. This technique has been used to provide new insights into the mode of action of the ruthenium‐based anticancer drug candidate indazolium [trans‐tetrachlorobis(1H‐indazole)ruthenate(III)] (KP1019). 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| source | MEDLINE; Wiley Online Library |
| subjects | Anticancer research Antineoplastic Agents - blood Antineoplastic Agents - chemistry Antineoplastic Agents - pharmacology Binding Sites Capillary electrophoresis (CE) Clinical Trials as Topic Deoxyguanine Nucleotides - chemistry DNA DNA - chemistry Electrophoresis, Capillary - methods Humans Indazoles - blood Indazoles - chemistry Indazoles - pharmacology KP1019 Mass spectrometry Mass Spectrometry - methods Molecular Conformation Organometallic Compounds Ruthenium complexes Ruthenium Compounds - blood Ruthenium Compounds - chemistry Ruthenium Compounds - pharmacology Serum Albumin - chemistry Spectrophotometry, Ultraviolet Structure-Activity Relationship |
| title | Elucidation of the Interactions of an Anticancer Ruthenium Complex in Clinical Trials with Biomolecules Utilizing Capillary Electrophoresis Hyphenated to Inductively Coupled Plasma-Mass Spectrometry. Short Communication |
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