Larvicidal Effects of Fungal Meroterpenoids in the Control of Aedes aegypti L., the Main Vector of Dengue and Yellow Fever
The mosquito Aedes aegypti is an increasing problem of public health, being the vector responsible for dengue and Yellow Fever in tropical and subtropical regions. The aim of this work was to determine the potential larvicidal activity of a series of meroterpenoids, compounds 1–7, previously obtaine...
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| Veröffentlicht in: | Chemistry & biodiversity 2008-02, Vol.5 (2), p.341-345 |
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| creator | Geris, Regina Rodrigues-Fo, Edson Garcia da Silva, Heloísa Helena Garcia da Silva, Ionizete |
| description | The mosquito Aedes aegypti is an increasing problem of public health, being the vector responsible for dengue and Yellow Fever in tropical and subtropical regions. The aim of this work was to determine the potential larvicidal activity of a series of meroterpenoids, compounds 1–7, previously obtained fungal secondary metabolites from Penicillium sp., against the third‐instar larvae of A. aegypti. The lethal concentrations (LC50 and LC90) of 1–7 were evaluated 24 h after exposure. Dehydroaustin (4) was the most active meroterpenoid in the series, with an LC50 value of 2.9 ppm, making it an attractive natural insecticide. |
| doi_str_mv | 10.1002/cbdv.200890032 |
| format | Article |
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Dehydroaustin (4) was the most active meroterpenoid in the series, with an LC50 value of 2.9 ppm, making it an attractive natural insecticide.</description><subject>Aedes - drug effects</subject><subject>Aedes aegypti</subject><subject>Animals</subject><subject>Dehydroaustin</subject><subject>Dengue</subject><subject>Dengue - prevention & control</subject><subject>Dose-Response Relationship, Drug</subject><subject>Insecticides</subject><subject>Insecticides - chemistry</subject><subject>Insecticides - metabolism</subject><subject>Insecticides - pharmacology</subject><subject>Larva - drug effects</subject><subject>Larvicidal activity</subject><subject>Lethal Dose 50</subject><subject>Meroterpenoids</subject><subject>Metabolites</subject><subject>Molecular Conformation</subject><subject>Mosquito</subject><subject>Mosquito Control - methods</subject><subject>Penicillium - chemistry</subject><subject>Stereoisomerism</subject><subject>Structure-Activity Relationship</subject><subject>Terpenes - chemistry</subject><subject>Terpenes - metabolism</subject><subject>Terpenes - pharmacology</subject><subject>Yellow Fever</subject><subject>Yellow Fever - prevention & control</subject><issn>1612-1872</issn><issn>1612-1880</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkE1PwkAQhjdGI4hePZr9AYL70Xa3RwVBk6IXxXjabLuzWK0t2S0o_nqLJejN00wmz_tm8iB0SsmAEsIustSsBowQGRPC2R7q0oiyPpWS7O92wTroyPvXhm_u8hB1qGQxDwLRRV-Jdqs8y40u8LW1kNUeVxaPl-W8uUzBVTW4BZRVbjzOS1y_AB5WZe2qYsNdggGPNczXizrHyeD8B5jqhpw1XZXbQCMo50vAujT4GYqi-sBjWIE7RgdWFx5OtrOHHsfXD8ObfnI_uR1eJv2My-b_QIRhxliappYDTSUJIm5FxEMtGANDmcgiIoCYmEobSs4CYzUnYAMiOUlj3kODtjdzlfcOrFq4_F27taJEbSSqjUS1k9gEztrAYpm-g_nFt9YaIG6Bj7yA9T91ang1mv0t77fZ3Nfwuctq96YiwUWonu4mKmajccwSqmb8G6cijIw</recordid><startdate>200802</startdate><enddate>200802</enddate><creator>Geris, Regina</creator><creator>Rodrigues-Fo, Edson</creator><creator>Garcia da Silva, Heloísa Helena</creator><creator>Garcia da Silva, Ionizete</creator><general>WILEY-VCH Verlag</general><general>WILEY‐VCH Verlag</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope></search><sort><creationdate>200802</creationdate><title>Larvicidal Effects of Fungal Meroterpenoids in the Control of Aedes aegypti L., the Main Vector of Dengue and Yellow Fever</title><author>Geris, Regina ; Rodrigues-Fo, Edson ; Garcia da Silva, Heloísa Helena ; Garcia da Silva, Ionizete</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3812-4755c22bbbf3e1b80463f7635a722ed127c607e0d918f58324dfa30ef40830b93</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2008</creationdate><topic>Aedes - drug effects</topic><topic>Aedes aegypti</topic><topic>Animals</topic><topic>Dehydroaustin</topic><topic>Dengue</topic><topic>Dengue - prevention & control</topic><topic>Dose-Response Relationship, Drug</topic><topic>Insecticides</topic><topic>Insecticides - chemistry</topic><topic>Insecticides - metabolism</topic><topic>Insecticides - pharmacology</topic><topic>Larva - drug effects</topic><topic>Larvicidal activity</topic><topic>Lethal Dose 50</topic><topic>Meroterpenoids</topic><topic>Metabolites</topic><topic>Molecular Conformation</topic><topic>Mosquito</topic><topic>Mosquito Control - methods</topic><topic>Penicillium - chemistry</topic><topic>Stereoisomerism</topic><topic>Structure-Activity Relationship</topic><topic>Terpenes - chemistry</topic><topic>Terpenes - metabolism</topic><topic>Terpenes - pharmacology</topic><topic>Yellow Fever</topic><topic>Yellow Fever - prevention & control</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Geris, Regina</creatorcontrib><creatorcontrib>Rodrigues-Fo, Edson</creatorcontrib><creatorcontrib>Garcia da Silva, Heloísa Helena</creatorcontrib><creatorcontrib>Garcia da Silva, Ionizete</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><jtitle>Chemistry & biodiversity</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Geris, Regina</au><au>Rodrigues-Fo, Edson</au><au>Garcia da Silva, Heloísa Helena</au><au>Garcia da Silva, Ionizete</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Larvicidal Effects of Fungal Meroterpenoids in the Control of Aedes aegypti L., the Main Vector of Dengue and Yellow Fever</atitle><jtitle>Chemistry & biodiversity</jtitle><addtitle>Chemistry & Biodiversity</addtitle><date>2008-02</date><risdate>2008</risdate><volume>5</volume><issue>2</issue><spage>341</spage><epage>345</epage><pages>341-345</pages><issn>1612-1872</issn><eissn>1612-1880</eissn><abstract>The mosquito Aedes aegypti is an increasing problem of public health, being the vector responsible for dengue and Yellow Fever in tropical and subtropical regions. 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| ispartof | Chemistry & biodiversity, 2008-02, Vol.5 (2), p.341-345 |
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| source | MEDLINE; Wiley Online Library Journals Frontfile Complete |
| subjects | Aedes - drug effects Aedes aegypti Animals Dehydroaustin Dengue Dengue - prevention & control Dose-Response Relationship, Drug Insecticides Insecticides - chemistry Insecticides - metabolism Insecticides - pharmacology Larva - drug effects Larvicidal activity Lethal Dose 50 Meroterpenoids Metabolites Molecular Conformation Mosquito Mosquito Control - methods Penicillium - chemistry Stereoisomerism Structure-Activity Relationship Terpenes - chemistry Terpenes - metabolism Terpenes - pharmacology Yellow Fever Yellow Fever - prevention & control |
| title | Larvicidal Effects of Fungal Meroterpenoids in the Control of Aedes aegypti L., the Main Vector of Dengue and Yellow Fever |
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