Transcription-Inhibition and Antitumor Activities of N-Alkylated Tetraazacyclododecanes

A series of alkyl‐substituted tetraazacyclododecane congeners were synthesized, and their antitumor activities towards human HeLa cells as well as their effect on the in vitro transcription with T7 RNA polymerase were investigated. A structure–activity‐relationship (SAR) study identified the most‐ac...

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Veröffentlicht in:Chemistry & biodiversity 2007-12, Vol.4 (12), p.2791-2797
Hauptverfasser: Xiong, Xiao-Qin, Liang, Feng, Yang, Li, Wang, Xiao-Lin, Zhou, Xiang, Zheng, Cong-Yi, Cao, Xiao-Ping
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Sprache:eng
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