Separation of product associating E. coli host cell proteins OppA and DppA from recombinant apolipoprotein A‐I Milano in an industrial HIC unit operation

We have shown how product associating E. coli host cell proteins (HCPs) OppA and DppA can be substantially separated from apolipoprotein A‐I Milano (apo A‐I M ) using Butyl Sepharose hydrophobic interaction chromatography (HIC). This work illustrates the complex problems that frequently arise during...

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Veröffentlicht in:	Biotechnology progress 2009-03, Vol.25 (2), p.446-453
Hauptverfasser:	Hunter, Alan K., Wang, Xing, Suda, Eric J., Herberg, John T., Shell, Robert E., Thomas, Kristin E., Dufield, Robert L., Gustafson, Mark E., Mozier, Ned M., Ho, Sa. V.
Format:	Artikel
Sprache:	eng
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