Liquid chromatography/mass spectrometry of plasma glucose and secreted glucuronate for metabolic studies in humans

Liquid chromatography/mass spectrometry of plasma glucose and secreted glucuronate for metabolic studies in humans

Negative ion thermospray liquid chromatographic/mass spectrometric methods have been developed for the determination of isotopic enrichments for glucose and acetaminophen—uridine diphosphate glucuronate from (1‐2H1)glucose, (1‐2H1)galactose and (2‐13C)acetate in humans. The error of estimate ranged...

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Veröffentlicht in:Biological Mass Spectrometry 1990-09, Vol.19 (9), p.535-540
Hauptverfasser: Reid, Steve, Shackleton, Cedric, Wu, Ken, Kaempfer, Suzanne, Hellerstein, Marc K.
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Sprache:eng
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Blood Glucose - analysis
Chromatography, Liquid
Glucuronates - blood
Humans
Mass Spectrometry
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container_end_page 540
container_issue 9
container_start_page 535
container_title Biological Mass Spectrometry
container_volume 19
creator Reid, Steve
Shackleton, Cedric
Wu, Ken
Kaempfer, Suzanne
Hellerstein, Marc K.
description Negative ion thermospray liquid chromatographic/mass spectrometric methods have been developed for the determination of isotopic enrichments for glucose and acetaminophen—uridine diphosphate glucuronate from (1‐2H1)glucose, (1‐2H1)galactose and (2‐13C)acetate in humans. The error of estimate ranged from below 1% to 5%. The advantages of the method include fast analysis (up to 35 per hour), eased sample preparation, good precision, sensitivity comparable with gas chromatography/mass spectrometry and better than with isotope ratio mass spectrometry.
doi_str_mv 10.1002/bms.1200190903
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1096-9888
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source MEDLINE; Wiley Online Library Journals Frontfile Complete; Alma/SFX Local Collection
subjects Blood Glucose - analysis
Chromatography, Liquid
Glucuronates - blood
Humans
Mass Spectrometry
title Liquid chromatography/mass spectrometry of plasma glucose and secreted glucuronate for metabolic studies in humans
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