Quantitation of the ataxia‐telangiectasia‐mutated and Rad3‐related inhibitor elimusertib (BAY‐1895344) in human plasma using LC–MS/MS

Ataxia‐telangiectasia‐mutated and Rad3‐related (ATR) is master regulator of the DNA‐damage response that, through multiple mechanisms, can promote cancer cell survival in response to replication stress from sources, including chemotherapy and radiation. Elimusertib (BAY‐1895344) is an orally availab...

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Veröffentlicht in:	Biomedical chromatography 2022-11, Vol.36 (11), p.e5455-n/a
Hauptverfasser:	Kiesel, Brian F., Parise, Robert A., Krishnamurthy, Anuradha, Gore, Steven, Beumer, Jan H.
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetonitriles assay Ataxia Telangiectasia ataxia‐telangiectasia mutated and Rad3‐related ATR inhibitor chromatography Chromatography, Liquid - methods DNA Humans MS/MS Protein Kinase Inhibitors Reproducibility of Results Tandem Mass Spectrometry - methods validation Water
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