Comparative bioavailability of two zolpidem hemitartrate formulations in healthy human Brazilian volunteers using high‐performance liquid chromatography coupled to tandem mass spectrometry

To assess the bioequivalence of two zolpidem hemitartrate formulations in 30 healthy volunteers. Plasma samples were obtained over a 24 h period. Plasma concentrations of zolpidem were analyzed by liquid chromatography coupled to tandem mass spectrometry with positive ion electrospray ionization usi...

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Veröffentlicht in:	Biomedical chromatography 2020-04, Vol.34 (4), p.e4731-n/a
Hauptverfasser:	Mendes, Gustavo D., Pereira, Thais da Silva, Rodrigues, Júlio César, Santos, Elaine Marcílio, Souza, Mariani Rafaela, Lopes‐Martins, Rodrigo Alvaro Brandão, Antunes, Natalícia de Jesus, Moreno, Ronilson Agnaldo, De Nucci, Gilberto
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult bioavailability Biological Availability Brazil Chromatography, High Pressure Liquid - methods Female Humans LC/MS/MS Limit of Detection Linear Models Male Middle Aged pharmacokinetics Reproducibility of Results Tablets tandem mass spectrometry Tandem Mass Spectrometry - methods Young Adult Zolpidem - blood Zolpidem - chemistry Zolpidem - pharmacokinetics
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